Routine and accurate data on deprivation are needed for urban planning and decision support at various scales (i.e., from community to international). However, analyzing information requirements of diverse users on urban deprivation, we found that data are often not available or inaccessible. To bridge this data gap, Earth Observation (EO) data can support access to frequently updated spatial information. However, a user-centered approach is urgently required for the production of EO-based mapping products. Combining an online survey and several forms of user interactions, we defined five system specifications (derived from user requirements) for designing an open-access spatial information system for deprived urban areas. First, gridded maps represent the optimal spatial granularity to deal with high uncertainties of boundaries of deprived areas and to protect privacy. Second, a high temporal granularity of 1-2 years is important to respond to the high spatial dynamics of urban areas. Third, detailed local-scale information should be part of a city-to-global information system. Fourth, both aspects, community assets and risks, need to be part of an information system, and such data need to be combined with local community-based information. Fifth, in particular, civil society and government users should have fair access to data that bridges the digital barriers. A data ecosystem on urban deprivation meeting these requirements will be able to support community-level action for improving living conditions in deprived areas, local science-based policymaking, and tracking progress towards global targets such as the SDGs.