The conflict between the vitality of natural ecosystem versus artificially developed systems has existed since decades. The ecological sensitivity and socio-economic aspects associated with riverfront development along rivers have attracted the attention of environmentalists and ecologists across the globe. The present study evaluates the impacts of channelization and riverfront development on the water quality of river Gomti through Water Pollution Index (WPI) and other statistical tools. Of the total studied sites, 75% were found to be in the 'highly polluted' category even after the development of riverfront. An approximate increase of 274.5% and 171.76% was witnessed in the WPI values at the midstream sites of Kudiaghat and Daliganj, respectively. This increase in the WPI values clearly stated the deteriorated water quality of river Gomti after the channelization. The major issue of domestic sewage discharge with partial or no treatment into the river seems to be unresolved even after a considerable period of riverfront development. This study can provide a reference database toward development of such projects across the globe.