The main aim of this paper is to perform the techno-economic and emissions analysis of energy generation from municipal solid waste (MSW) considering two alternative technological options: incineration (INC) and anaerobic digestion (AD). We identify the role of various parameters in estimating the techno-economic and climate change impact in the two scenarios. We explore the uncertainty in the estimation and identify the most influential parameters using Monte-Carlo simulation. A case study in the management of household solid waste in the city of Curitiba is evaluated. Energy and GHG emissions in single and hybrid pathways are explored. The results show that the incineration option can produce 170-430 GWh/year of electricity whereas AD plant will generate 10-70 GWh/year. Emissions are estimated at the range 38-150 millionkgCO2eq (INC) and 5-60 millionkgCO2eq (AD). The key influencing parameters are: organic fraction of MSW, non-biogenetic composition, electrical efficiency, methane leakage, and fraction of fossil carbon in waste. Even if the incineration option can produce more energy, the technology not only emits a significant amount of emissions but also nutrient and key resources will be lost. The levelized cost of electricity (LCOE) production from the INC and AD systems is estimated at 0.071-0.124 USD/kWh and 0.086-0.227 USD/kWh respectively. AD options will favor the circularity concept when the full potential of the resource is recovered. For this, better planning and logistics along with an innovative business model, are required. The model developed in the study can be used in other cities in the management of their MSW.