Mitochondrial Targeting Probes, Drug Conjugates, and Gene Therapeutics
2022 (English)In: Cell Penetrating Peptides, Springer Nature , 2022, p. 429-446Chapter in book (Refereed)
Abstract [en]
Mitochondria represent an important drug target for many phatology, including neurodegeneration, metabolic disease, heart failure, ischemia-reperfusion injury, and cancer. Mitochondrial dysfunctions are caused by mutation in mitochondrial DNA or in nuclear genes encoding mitochondrial proteins. Cell-penetrating peptides (CPPs) have been employed to overcome biological barriers, target this organelle, and therapeuticaly restore mitochondrial functions. Here, we describe recent methods used to deliver oligonucleotides targeting mitochondrial protein by using mitochondrial penetrating peptides. In particular, we highlight recent advances of formulated peptides/oligonucleotides nanocomplexes as a proof-of-principle for pharmaceutical form of peptide-based therapeutics.
Place, publisher, year, edition, pages
Springer Nature , 2022. p. 429-446
Series
Methods in Molecular Biology
Keywords [en]
Intracellular delivery, mitFects, Mitochondria, Nanocarriers, Nanoparticles, 1 methyl 2 pyrrolidinone, amino acid, antisense oligonucleotide, cell penetrating peptide, mitFects peptide, mitochondrial protein, n, n dimethylformamide, nanoparticle, stearic acid, unclassified drug, drug, oligonucleotide, clinical feature, clinical trial (topic), complex formation, confocal microscopy, disorders of mitochondrial functions, drug conjugation, drug delivery system, drug development, drug targeting, gene targeting, gene therapy, HeLa cell line, high performance liquid chromatography, human, human cell, in vitro study, internalization (cell), mitochondrial gene, peptide library, peptide synthesis, protein analysis, protein purification, synthesis, zeta potential, genetics, mitochondrion, Cell-Penetrating Peptides, Drug Delivery Systems, Mitochondrial Proteins, Oligonucleotides, Pharmaceutical Preparations
National Category
Physical Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-313170DOI: 10.1007/978-1-0716-1752-6_27PubMedID: 34766305Scopus ID: 2-s2.0-85119149999OAI: oai:DiVA.org:kth-313170DiVA, id: diva2:1663420
Note
QC 20220602
2022-06-022022-06-022022-06-25Bibliographically approved