kth.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
MRI characterization of skeletal muscle size and fatty infiltration in long--term trained and untrained individuals
Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden..
Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Orthopaed Surg, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA..
Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Systems Biology. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-2261-0881
Show others and affiliations
2022 (English)In: Physiological Reports, E-ISSN 2051-817X, Vol. 10, no 14, article id e15398Article in journal (Refereed) Published
Abstract [en]

This study investigated body composition measures in highly trained and untrained individuals using whole--body magnetic resonance imaging (MRI). Additionally, correlations between these measures and skeletal muscle gene expression were performed. Thirty-six individuals were included: endurance-trained males (ME, n = 8) and females (FE, n = 7), strength-trained males (MS, n = 7), and untrained control males (MC, n = 8) and females (FC, n = 6). MRI scans were performed, and resting M. vastus lateralis (VL) biopsies were subjected to RNA sequencing. Liver fat fraction, visceral adipose tissue volume (VAT), total body fat, and total lean tissue were measured from MRI data. Additionally, cross-sectional area (CSA) and fat signal fraction (FSF) were calculated from Mm. pectoralis, M. erector spinae and M. multifidus combined, Mm. quadriceps, and Mm. triceps surae (TS). Liver fat fraction, VAT, and total body fat relative to body weight were lower in ME and FE compared with corresponding controls. MS had a larger CSA across all four muscle groups and lower FSF in all muscles apart from TS compared with MC. ME had a lower FSF across all muscle groups and a larger CSA in all muscles except TS than MC. FE athletes showed a higher CSA in Mm. pectoralis and Mm. quadriceps and a lower CSA in TS than FC with no CSA differences found in the back muscles investigated. Surprisingly, the only difference in FSF between FE and FC was found in Mm. pectoralis. Lastly, correlations between VL gene expression and VL CSA as well as FSF showed that genes positively correlated with CSA revealed an enrichment of the oxidative phosphorylation and thermogenesis pathways, while the genes positively correlated with FSF showed significant enrichment of the spliceosome pathway. Although limited differences were found with training in females, our study suggests that both regular endurance and resistance training are useful in maintaining muscle mass, reducing adipose tissue deposits, and reducing muscle fat content in males.

Place, publisher, year, edition, pages
Wiley , 2022. Vol. 10, no 14, article id e15398
Keywords [en]
adipose tissue, endurance training, human, resistance training
National Category
Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:kth:diva-315932DOI: 10.14814/phy2.15398ISI: 000827301200001PubMedID: 35854646Scopus ID: 2-s2.0-85134635326OAI: oai:DiVA.org:kth-315932DiVA, id: diva2:1684727
Note

QC 20220728

Available from: 2022-07-28 Created: 2022-07-28 Last updated: 2023-06-08Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Arif, MuhammadMardinoglu, Adil

Search in DiVA

By author/editor
Arif, MuhammadMardinoglu, Adil
By organisation
Systems BiologyScience for Life Laboratory, SciLifeLab
In the same journal
Physiological Reports
Sport and Fitness Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 56 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf