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Engineering a partially spatially coherent light source and study of its implication on time-domain Full- Field Optical Coherence Tomography
KTH, School of Engineering Sciences (SCI), Applied Physics.
2022 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
Design och karakterisering av partiellt koherent ljuskälla för Optisk koherens-tomografi med stort bildfält (Swedish)
Abstract [en]

Full-Field Optical Coherence Tomography (FFOCT) is a groundbreaking imaging modality in ophthalmology. FFOCT is a high-speed, large field-of-view, and high-resolution technique, which for instance makes it possible to precisely image photoreceptor cells on the retina. One of the current main limitations lies in the lack of sensitivity, meaning that very transparent cells, such as retinal ganglion cells, remain invisible. This is due to the low radiance of the current source: the Light-Emitting Diode (LED). Yet due to its spatial incoherence, LED has numerous benefits for FFOCT: homogeneous illumination on the sample, high lateral resolution, robustness to aberrations, and reduced crosstalk noise in the image. Therefore, the aim of thisthesis is to engineer a new illumination module that combines spatial incoherence and high radiance.After considering the alternatives, the choice was to use a Superluminescent Diode (SLD) coupled to a multimode fiber. Different multimode fibers were ordered, and tools were developed to evaluate the relevant performance criteria: homogeneity of the illumination spot, resolution, and robustness to aberrations. The fiber yielding the best homogeneity of illumination was selected. Then, resolution, and robustness to optical aberrations of the FFOCT system were characterized and compared to LED illumination. The results of the experiments showed that the module composed of an SLD and a multimode fiber represents an in-between in terms of performance, compared to the LED alone (current reference) and to the SLD alone. To become asbeneficial as the LED, this module still requires adjustments, such as ensuring that all the modes in the multimode fiber are excited.

Abstract [sv]

Full-Field Optical Coherence Tomography (FFOCT) öppnar nya möjligheter inom oftalmologi. Då metoden är snabb, har hög upplösning och stort bildfält kan den till exempel användas för att se syncellerna på näthinnan. För närvarande begränsas metoden av låg sensibilitet, vilket gör att genomskinliga celler, såsom gangliecellerna i näthinnan, inte syns. Begränsningen ligger i att den nuvarande ljuskällan, Light Emitting DIode (LED), har för låg radians. Samtidigt ger LED inkoherent belysning, vilket leder till jämn belysning av objektet, hög upplösning, och minskad överhörning i brus. Denna avhandling sysftar till att skapa en belysningsmodul med högre radians än LED, som fortfarande ger inkoherent belysning.Valet föll på an Superluminischent diod (SLD) i konmination med en multimod-fiber. Olika fibrer testades med avseende på belysningens jämnhet, bildens upplösning samt känslighet för aberrationer. Verktyg för att undersöka dessa egenskaper utvecklades. Fibern med jämnast belysning valdes, och testades med avseende på upplösning och känslighet för defokus. Resultaten jämfördes med LED-belysning. SLD i kombination med en multimodfiber gav fortfarande sämre kvalitet än LED, men avsevärt bättre än SLD utan fiber. För att ytterligare förbättra resultaten bör man utveckla konceptet, bland annat genom att utnyttja fiberns alla moder.

Place, publisher, year, edition, pages
2022.
Series
TRITA-SCI-GRU ; 2022:180
Keywords [en]
FFOCT, LED, SLD, multimode fibers, spatial coherence, speckle contrast, resolution, optical aberrations
Keywords [sv]
FFOCT, LED, SLD, multimodfiber, spatial koherens, speckel-konstrast, upplösning, optiska aberrationer
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-317495OAI: oai:DiVA.org:kth-317495DiVA, id: diva2:1695153
External cooperation
The Quinze-Vingts National Ophthalmology Hospital
Subject / course
Physics
Educational program
Master of Science - Engineeering Physics
Examiners
Available from: 2022-09-13 Created: 2022-09-13 Last updated: 2022-09-13Bibliographically approved

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