kth.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Host-mycobiome metabolic interactions in health and disease
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England..ORCID iD: 0000-0003-4408-8940
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England..
Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England..ORCID iD: 0000-0002-6428-5936
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Systems Biology.ORCID iD: 0000-0002-4858-8056
Show others and affiliations
2022 (English)In: Gut microbes, ISSN 1949-0976, E-ISSN 1949-0984, Vol. 14, no 1, article id e2121576Article, review/survey (Refereed) Published
Abstract [en]

Fungal communities (mycobiome) have an important role in sustaining the resilience of complex microbial communities and maintenance of homeostasis. The mycobiome remains relatively unexplored compared to the bacteriome despite increasing evidence highlighting their contribution to host-microbiome interactions in health and disease. Despite being a small proportion of the total species, fungi constitute a large proportion of the biomass within the human microbiome and thus serve as a potential target for metabolic reprogramming in pathogenesis and disease mechanism. Metabolites produced by fungi shape host niches, induce immune tolerance and changes in their levels prelude changes associated with metabolic diseases and cancer. Given the complexity of microbial interactions, studying the metabolic interplay of the mycobiome with both host and microbiome is a demanding but crucial task. However, genome-scale modelling and synthetic biology can provide an integrative platform that allows elucidation of the multifaceted interactions between mycobiome, microbiome and host. The inferences gained from understanding mycobiome interplay with other organisms can delineate the key role of the mycobiome in pathophysiology and reveal its role in human disease.

Place, publisher, year, edition, pages
Informa UK Limited , 2022. Vol. 14, no 1, article id e2121576
Keywords [en]
Mycobiome, microbiome, metabolism, host-mycobiome interaction, systems biology, secondary metabolism
National Category
Microbiology
Identifiers
URN: urn:nbn:se:kth:diva-320316DOI: 10.1080/19490976.2022.2121576ISI: 000859683700001PubMedID: 36151873Scopus ID: 2-s2.0-85138459386OAI: oai:DiVA.org:kth-320316DiVA, id: diva2:1705875
Note

QC 20221024

Available from: 2022-10-24 Created: 2022-10-24 Last updated: 2024-03-15Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Lee, SunjaeUhlén, MathiasShoaie, Saeed

Search in DiVA

By author/editor
Begum, NeeluLee, SunjaeUhlén, MathiasMoyes, David L.Shoaie, Saeed
By organisation
Science for Life Laboratory, SciLifeLabSystems Biology
In the same journal
Gut microbes
Microbiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 157 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf