In cloud manufacturing systems, fault diagnosis is essential for ensuring stable manufacturing processes. The most crucial performance indicators of fault diagnosis models are generalization and accuracy. An urgent problem is the lack and imbalance of fault data. To address this issue, in this article, most of existing approaches demand the label of faults as a priori knowledge and require extensive target fault data. These approaches may also ignore the heterogeneity of various equipment. We propose a cloud-edge collaborative method for adaptive fault diagnosis with label sampling space enlarging, named label-split multiple-inputs convolutional neural network, in cloud manufacturing. First, a multiattribute cooperative representation-based fault label sampling space enlarging approach is proposed to extend the variety of diagnosable faults. Besides, a multi-input multi-output data augmentation method with label-coupling weighted sampling is developed. In addition, a cloud-edge collaborative adaptation approach for fault diagnosis for scene-specific equipment in cloud manufacturing system is proposed. Experiments demonstrate the effectiveness and accuracy of our method.