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Gaussian process modeling of macroscopic kinetics: a better-tailored kernel for Monod-type kinetics
KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control). KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Centre for Advanced BioProduction by Continuous Processing, AdBIOPRO.ORCID iD: 0000-0003-2008-0127
KTH, School of Electrical Engineering and Computer Science (EECS), Intelligent systems, Decision and Control Systems (Automatic Control). KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Centre for Advanced BioProduction by Continuous Processing, AdBIOPRO.ORCID iD: 0000-0002-9368-3079
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Industrial Biotechnology. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Centres, Centre for Advanced BioProduction by Continuous Processing, AdBIOPRO.ORCID iD: 0000-0002-5370-4621
2022 (English)In: 10th Vienna International Conference on Mathematical Modelling MATHMOD 2022 Vienna Austria, 27–29 July 2022, Elsevier BV , 2022, Vol. 55, no 20, p. 397-402Conference paper, Published paper (Refereed)
Abstract [en]

In bioprocesses, it is important to model the kinetics of the macroscopic rates of reactions since these are required to catch the dynamical aspects of a process. In [Wang et al. 2020], a modeling method involving Gaussian processes has been developed, using a kernel especially designed for the modeling of Monod-type kinetics (activation, inhibition, double component, neutral effect). However, as will be illustrated in this paper, when the number of training data is limited or the metabolite concentration data do not have large variations (which is generally the case for real-life data), this kernel can yield inaccurate models for the kinetics. In this paper, we develop a new kernel better tailored for the modeling of Monod-type kinetics and we show that it has good modeling performances in the case of a limited number of data. The idea is to use the particular structure of Monod-type functions in the design of the kernel, i.e., we incorporate prior knowledge in the modeling.

Place, publisher, year, edition, pages
Elsevier BV , 2022. Vol. 55, no 20, p. 397-402
Series
IFAC PAPERSONLINE, ISSN 2405-8963 ; 55
Keywords [en]
Gaussian process, Nonlinear system identification, Monod model, Kinetics, Macroscopic modeling
National Category
Control Engineering
Research subject
Chemical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-320408DOI: 10.1016/j.ifacol.2022.09.127ISI: 000860842100067Scopus ID: 2-s2.0-85142254386OAI: oai:DiVA.org:kth-320408DiVA, id: diva2:1709859
Conference
10th Vienna International Conference on Mathematical Modelling (MATHMOD), JUL 27-29, 2022, Tech Univ Wien, ELECTR NETWORK
Projects
Competence center AdBIOPRO
Note

QC 20221110

Available from: 2022-11-10 Created: 2022-11-10 Last updated: 2024-02-07Bibliographically approved

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Colin, KevinHjalmarsson, HåkanChotteau, Véronique

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