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Portable Quartz Crystal Resonator Sensor for Characterising the Gelation Kinetics and Viscoelastic Properties of Hydrogels
Univ Politecn Madrid UPM, Ctr Biomed Technol CTB, Madrid 28040, Spain..ORCID iD: 0000-0001-8725-5089
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Glycoscience. KTH, Centres, Center for the Advancement of Integrated Medical and Engineering Sciences, AIMES. Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden..ORCID iD: 0000-0001-7257-5522
Swedish Univ Agr Sci, Dept Forest Biomat & Technol, Div Wood Sci & Technol, SLU, S-75651 Uppsala, Sweden..
Univ Politecn Madrid UPM, Ctr Biomed Technol CTB, Madrid 28040, Spain.;Univ Politecn Madrid UPM, Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Madrid 28040, Spain..
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2022 (English)In: Gels, E-ISSN 2310-2861, Vol. 8, no 11, p. 718-, article id 718Article in journal (Refereed) Published
Abstract [en]

Hydrogel biomaterials have found use in various biomedical applications partly due to their biocompatibility and tuneable viscoelastic properties. The ideal rheological properties of hydrogels depend highly on the application and should be considered early in the design process. Rheometry is the most common method to study the viscoelastic properties of hydrogels. However, rheometers occupy much space and are costly instruments. On the other hand, quartz crystal resonators (QCRs) are devices that can be used as low-cost, small, and accurate sensors to measure the viscoelastic properties of fluids. For this reason, we explore the capabilities of a low-cost and compact QCR sensor to sense and characterise the gelation process of hydrogels while using a low sample amount and by sensing two different crosslink reactions: covalent bonds and divalent ions. The gelation of covalently crosslinked mucin hydrogels and physically crosslinked alginate hydrogels could be monitored using the sensor, clearly distinguishing the effect of several parameters affecting the viscoelastic properties of hydrogels, including crosslinking chemistry, polymer concentrations, and crosslinker concentrations. QCR sensors offer an economical and portable alternative method to characterise changes in a hydrogel material's viscous properties to contribute to this type of material design, thus providing a novel approach.

Place, publisher, year, edition, pages
MDPI AG , 2022. Vol. 8, no 11, p. 718-, article id 718
Keywords [en]
covalently crosslinked hydrogels, hydrogel kinetics characterisation, physically crosslinked hydrogels, quartz crystal resonator
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-321908DOI: 10.3390/gels8110718ISI: 000883950900001PubMedID: 36354626Scopus ID: 2-s2.0-85141703911OAI: oai:DiVA.org:kth-321908DiVA, id: diva2:1716656
Note

QC 20221206

Available from: 2022-12-06 Created: 2022-12-06 Last updated: 2022-12-06Bibliographically approved

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Yan, HongjiCrouzier, Thomas

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Miranda-Martinez, AndresYan, HongjiCrouzier, Thomas
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GlycoscienceCenter for the Advancement of Integrated Medical and Engineering Sciences, AIMES
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