Portable Quartz Crystal Resonator Sensor for Characterising the Gelation Kinetics and Viscoelastic Properties of Hydrogels Show others and affiliations
2022 (English) In: Gels, E-ISSN 2310-2861, Vol. 8, no 11, p. 718-, article id 718Article in journal (Refereed) Published
Abstract [en]
Hydrogel biomaterials have found use in various biomedical applications partly due to their biocompatibility and tuneable viscoelastic properties. The ideal rheological properties of hydrogels depend highly on the application and should be considered early in the design process. Rheometry is the most common method to study the viscoelastic properties of hydrogels. However, rheometers occupy much space and are costly instruments. On the other hand, quartz crystal resonators (QCRs) are devices that can be used as low-cost, small, and accurate sensors to measure the viscoelastic properties of fluids. For this reason, we explore the capabilities of a low-cost and compact QCR sensor to sense and characterise the gelation process of hydrogels while using a low sample amount and by sensing two different crosslink reactions: covalent bonds and divalent ions. The gelation of covalently crosslinked mucin hydrogels and physically crosslinked alginate hydrogels could be monitored using the sensor, clearly distinguishing the effect of several parameters affecting the viscoelastic properties of hydrogels, including crosslinking chemistry, polymer concentrations, and crosslinker concentrations. QCR sensors offer an economical and portable alternative method to characterise changes in a hydrogel material's viscous properties to contribute to this type of material design, thus providing a novel approach.
Place, publisher, year, edition, pages MDPI AG , 2022. Vol. 8, no 11, p. 718-, article id 718
Keywords [en]
covalently crosslinked hydrogels, hydrogel kinetics characterisation, physically crosslinked hydrogels, quartz crystal resonator
National Category
Polymer Chemistry
Identifiers URN: urn:nbn:se:kth:diva-321908 DOI: 10.3390/gels8110718 ISI: 000883950900001 PubMedID: 36354626 Scopus ID: 2-s2.0-85141703911 OAI: oai:DiVA.org:kth-321908 DiVA, id: diva2:1716656
Note QC 20221206
2022-12-062022-12-062022-12-06 Bibliographically approved