This study proposes a model describing the functions and procedures for configuring the transmission of data of Digital Twins (DT) in humancenteredCyber-Physical Systems (CPS). We draw data from two cases including aircraft manufacturing and production logistics and presenttwo contributions. First, we derive a procedure identifying the steps and resources of data processing for DT in human-centered CPS. Second,we propose a systematic procedure for configuring bi-directional data transmission depending on the desired system utilization. These resultscontribute to realizing data processing activities supporting the implementation of DTs for human-centered CPS in manufacturing.