The Middle East (ME) is grappling with an alarming increase in dust levels, measured as aerosol optical depth (AOD), which poses significant threats to air quality, human health, and ecological stability. This study aimed to investigate correlations between climate and non-climate driving factors and AOD in the ME over the last four-decade (1980–2020), based on analysis of three variables: actual evapotranspiration (AET), potential evapotranspiration (PET), and precipitation (P). A comprehensive analysis is conducted to discern patterns and trends, with a particular focus on regions such as Rub al-Khali, Ad-Dahna, An-Nafud Desert, and southern Iraq, where consistently high dust levels were observed. 77 % of the study area is classified as arid or semi-arid based on the aridity index. Our results indicate an upward trend in dust levels in Iraq, Iran, Yemen, and Saudi Arabia. We noted an increasing AET trend in regions such as the Euphrates and Tigris basin, northern-Iran, and the Nile region, along with rising PET levels in arid and semi-arid zones such as Iran, Iraq, and Syria. Conversely, P showed a notable decrease in northern-Iraq, Syria, southwestern Iran, and southern-Turkey. Comparison of long-term changes (10-year moving averages) of AOD and P showed a consistent increase in AOD with P levels decreasing in all climate regions. The Budyko space analysis indicates shifts in evaporation ratio across different climate classes from 1980 to 2020, with predominant movement patterns towards higher aridity indices in arid and semi-arid regions, while factors beyond long-term aridity changes influence shifts in evaporation ratio across various climatic zones. The Middle East experiences complex and intricate interactions between dust events and their drivers. To address this issue, a comprehensive and multi-system approach is necessary, which considers both climate and non-climate drivers. Moreover, an efficient dust control strategy should include soil and water conservation, advanced monitoring, and public awareness campaigns that involve regional and international collaboration.