Impact of deep-learning CT image denoising on the accuracy of radiomics parameter estimation
2024 (English)In: Medical Imaging 2024: Physics of Medical Imaging, SPIE-Intl Soc Optical Eng , 2024, article id 129252CConference paper, Published paper (Refereed)
Abstract [en]
In CT radiomics, numerical parameters extracted from CT images are analyzed to find biomarkers. Since these numerical parameters can vary with imaging parameters, there is a need to optimize acquisition protocols for radiomics. In this work, we investigate the effect of deep-learning-based image reconstruction on the accuracy of radiomic parameters of tumors. We image a 3D printed lung phantom containing four tumors (ellipsoidal, lobulated, spherical, and spiculated), using the CAD model as ground truth. The phantom was 3D printed using fused deposition modeling with a PLA filament and 80% fill rate with a gyroidal pattern to mimic soft tissue. CT images of the 3D printed phantom and tumors were acquired with a GE revolution scanner with 120 kVp and 213 mAs. We reconstructed images using FBP and a vendor-supplied deep learning image reconstruction (DLIR) method (TrueFidelity, GE HealthCare). We also applied 24 custom convolutional neural network denoisers with a U-net architecture, trained on the AAPM-Mayo Clinic Low Dose CT dataset. After segmentation, 14 radiomic features were extracted using SlicerRadiomics. Results show that the vendor-supplied DLIR gave a smaller relative error than FBP for 87% of radiomic features. 8 out of 24 custom denoisers yielded a smaller error than FBP in 50% or more of the radiomic measurements. One denoiser, (VGG16+L1 loss, 32 features, batch size 16), outperformed FBP in 84% of measurements and outperformed the vendor-supplied DLIR in 63% of the measurements. In conclusion, our results demonstrate that deep-learning-based denoising has the potential to improve the accuracy of CT radiomics.
Place, publisher, year, edition, pages
SPIE-Intl Soc Optical Eng , 2024. article id 129252C
Keywords [en]
Computer Tomography, Deep Learning, Machine Learning, Perceptual loss, Radiomics
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-347136DOI: 10.1117/12.3006732ISI: 001223517100071Scopus ID: 2-s2.0-85193518465OAI: oai:DiVA.org:kth-347136DiVA, id: diva2:1864385
Conference
Medical Imaging 2024: Physics of Medical Imaging, San Diego, United States of America, Feb 19 2024 - Feb 22 2024
Note
Part of proceedings ISBN: 978-151067154-6
QC 20240610
2024-06-032024-06-032024-06-14Bibliographically approved