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Impact of deep-learning CT image denoising on the accuracy of radiomics parameter estimation
KTH, School of Engineering Sciences (SCI), Physics.
KTH, School of Engineering Sciences (SCI), Physics.
KTH, School of Engineering Sciences (SCI), Physics.
KTH, School of Engineering Sciences (SCI), Physics.ORCID iD: 0000-0002-5092-8822
2024 (English)In: Medical Imaging 2024: Physics of Medical Imaging, SPIE-Intl Soc Optical Eng , 2024, article id 129252CConference paper, Published paper (Refereed)
Abstract [en]

In CT radiomics, numerical parameters extracted from CT images are analyzed to find biomarkers. Since these numerical parameters can vary with imaging parameters, there is a need to optimize acquisition protocols for radiomics. In this work, we investigate the effect of deep-learning-based image reconstruction on the accuracy of radiomic parameters of tumors. We image a 3D printed lung phantom containing four tumors (ellipsoidal, lobulated, spherical, and spiculated), using the CAD model as ground truth. The phantom was 3D printed using fused deposition modeling with a PLA filament and 80% fill rate with a gyroidal pattern to mimic soft tissue. CT images of the 3D printed phantom and tumors were acquired with a GE revolution scanner with 120 kVp and 213 mAs. We reconstructed images using FBP and a vendor-supplied deep learning image reconstruction (DLIR) method (TrueFidelity, GE HealthCare). We also applied 24 custom convolutional neural network denoisers with a U-net architecture, trained on the AAPM-Mayo Clinic Low Dose CT dataset. After segmentation, 14 radiomic features were extracted using SlicerRadiomics. Results show that the vendor-supplied DLIR gave a smaller relative error than FBP for 87% of radiomic features. 8 out of 24 custom denoisers yielded a smaller error than FBP in 50% or more of the radiomic measurements. One denoiser, (VGG16+L1 loss, 32 features, batch size 16), outperformed FBP in 84% of measurements and outperformed the vendor-supplied DLIR in 63% of the measurements. In conclusion, our results demonstrate that deep-learning-based denoising has the potential to improve the accuracy of CT radiomics.

Place, publisher, year, edition, pages
SPIE-Intl Soc Optical Eng , 2024. article id 129252C
Keywords [en]
Computer Tomography, Deep Learning, Machine Learning, Perceptual loss, Radiomics
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-347136DOI: 10.1117/12.3006732ISI: 001223517100071Scopus ID: 2-s2.0-85193518465OAI: oai:DiVA.org:kth-347136DiVA, id: diva2:1864385
Conference
Medical Imaging 2024: Physics of Medical Imaging, San Diego, United States of America, Feb 19 2024 - Feb 22 2024
Note

Part of proceedings ISBN: 978-151067154-6

QC 20240610

Available from: 2024-06-03 Created: 2024-06-03 Last updated: 2024-06-14Bibliographically approved

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Pandurevic, PontusBack, AlexHein, DennisPersson, Mats

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