Knowledge management technology is now ubiquitous in many businesses, yet it is much less common among local authorities. Following a "brainstorm meeting" in Lyon on knowledge management for regional planning and policymaking, a proposal was developed to set up a research agendum for future development of this topic. The main difficulty we identified is that regional knowledge encompasses many topics beyond business issues, especially those related to long-term sustainability. The goal of this paper is twofold, first to clarify the proper definitions and boundaries of regional knowledge and technology, and second, to identify the ways of using this technology effectively for governance and decision-making.