Widely recognized as a valuable model for designing and developing online courses, the Community of Inquiry (CoI) framework conceptualizes the online learning experience as a dynamic interplay between three key elements: social presence, teaching presence, and cognitive presence. This chapter provides background on the CoI framework and how it is conceptually situated. Current research related to the CoI, the three presences, empirical methods, and disciplinary differences are also discussed. Meanwhile, there is a great deal of research to date that uses the CoI as a lens, and many include practical implications, yet there has been limited guidance (Fiock, 2020; Garrison, 2017, Richardson et al., 2012) readily available for designers looking to create an online community of inquiry with the CoI guiding principles in mind. This chapter revisits the seven design principles and synthesizes evidence-based approaches for each that can be practically implemented.