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Electrophoretic Heating of Gold Nanoparticles in Water and Human Tissue
KTH, School of Electrical Engineering and Computer Science (EECS).
KTH, School of Electrical Engineering and Computer Science (EECS).
2024 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Heating of gold nanoparticles with radiofrequency can potentially be used as aninnovative approach to cancer treatment without serious side effects. This study investigatesthe heating mechanisms of gold nanoparticles under radiofrequency, with a focus onelectrophoretic heating using scattering theory. The study involves theoretical modeling ofthe gold nanoparticles behavior in water and human tissue environments. Key outcomesinclude parameter studies on particle size, charge, and frequency to optimize absorption inwater, along with calculations demonstrating the minimal impact of gold nanoparticles oncancerous tissue heating due to the dielectric and thermal properties of the tissue. Theresults indicate that electrophoretic heating using scattering theory could potentially describethe heating mechanisms of gold nanoparticles. The increase in the temperature of canceroustissue with the presence of gold nanoparticles under radiofrequency is negligible, highlightingthe critical role of the host medium's dielectric properties.

Abstract [sv]

Uppvärmning av guldnanopartiklar med radiofrekvens kan potentielltanvändas som en innovativ metod inom cancerbehandling utan allvarliga biverkningar.Denna studie undersöker mekanismerna bakom uppvärmningen av guldnanopartiklar underradiofrekvens, med fokus på elektroforetisk uppvärmning med hjälp av spridningsteori.Studien innefattar teoretisk modellering av guld nanopartiklars beteende i vatten ochmänsklig vävnad. Nyckelresultaten består av parameterstudier om partikelstorlek, laddningoch frekvens för att optimera absorption i vatten, tillsammans med beräkningar som visarden minimala påverkan guldnanopartiklar har på uppvärmning av cancervävnad på grund avvävnadens dielektriska och termiska egenskaper. Resultaten indikerar att elektroforetiskuppvärmning med spridningsteori potentiellt kan beskriva uppvärmningen hosguldnanopartiklar. Temperaturökningen hos cancervävnad med närvaron avguldnanopartiklar under radiofrekvens är försumbar, vilket understryker den väsentliga rollenhos värdmediets dielektriska egenskaper.

Place, publisher, year, edition, pages
2024. , p. 357-364
Series
TRITA-EECS-EX ; 2024:164
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:kth:diva-358953OAI: oai:DiVA.org:kth-358953DiVA, id: diva2:1931079
Supervisors
Examiners
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Kandidatexamensarbete Elektroteknik EECS 2024Available from: 2025-01-24 Created: 2025-01-24

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CiteExportLink to record
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