This article examines the relationship between settler colonialism and the rise of mineral-intensive industrial manufacturing in the United States. Land expropriated from Anishinaabe nations in what is currently the Upper Peninsula of the state of Michigan was one of the largest sources of copper for nineteenth-century U.S. industrial capitalists. The U.S. takeover of mineral-rich Anishinaabe land reflects the early union of settler colonial ambitions for the Great Lakes region with an emerging political economy of national self-sufficiency by way of continental supplies of raw materials typically imported from overseas. After the War of 1812, U.S. officials imagined the transformation of Anishinaabewaki into the material basis of an independent U.S. copper industry. Accordingly, they employed geologists to conduct fieldwork within Indigenous territories to help guide and facilitate the process of treaty making. However, the authority of the United States remained weak where they had little control over commerce and could not depend on the pressures of encroaching settler populations. Only by granting and enforcing a trade monopoly with the American Fur Company were U.S. leaders able to make inroads toward their goals of acquiring territorial control over the raw materials of industrial capitalism and dispossessing the Anishinaabeg.