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Macrophage activation phenotypes in type 1 diabetes pathogenesis and therapy: Master thesis
KTH, School of Biotechnology (BIO). (Molecular Biotechnology)
2009 (English)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Macrophages are an important key effector cell in the immune system which can practically be found in every tissue. Macrophages have for a long time been considered a population of cells only responsible for pro-inflammatory responses and anti-microbial activities. But over the past decade, many have come to realize the amazing plasticity of macrophages in response to different stimulations. The anti-microbial and pro-inflammatory macrophage is known as classically activated macrophages but newly discovered phenotypes have been revealed named wound-healing macrophages and regulatory macrophages. Through systematic screening we have identified an inducible macrophage activation state which has both wound-healing and regulatory capabilities activated by the novel cytokine combination IL-4/IL-10 with or without TGF-β.

Place, publisher, year, edition, pages
2009. , 25 p.
Keyword [en]
regulatory macrophages type I diabetes immunology autoimmunity
National Category
Immunology in the medical area
URN: urn:nbn:se:kth:diva-10210OAI: diva2:211075
2009-03-06, Bioteknologi, Plan 3, Roslagstullsbacken 21 level 3, Stockholm, 14:00 (English)
Available from: 2009-06-23 Created: 2009-04-07 Last updated: 2010-04-28

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Parsa, Roham
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