Macrophage activation phenotypes in type 1 diabetes pathogenesis and therapy: Master thesis
Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
Macrophages are an important key effector cell in the immune system which can practically be found in every tissue. Macrophages have for a long time been considered a population of cells only responsible for pro-inflammatory responses and anti-microbial activities. But over the past decade, many have come to realize the amazing plasticity of macrophages in response to different stimulations. The anti-microbial and pro-inflammatory macrophage is known as classically activated macrophages but newly discovered phenotypes have been revealed named wound-healing macrophages and regulatory macrophages. Through systematic screening we have identified an inducible macrophage activation state which has both wound-healing and regulatory capabilities activated by the novel cytokine combination IL-4/IL-10 with or without TGF-β.
Place, publisher, year, edition, pages
2009. , 25 p.
regulatory macrophages type I diabetes immunology autoimmunity
Immunology in the medical area
IdentifiersURN: urn:nbn:se:kth:diva-10210OAI: oai:DiVA.org:kth-10210DiVA: diva2:211075
2009-03-06, Bioteknologi, Plan 3, Roslagstullsbacken 21 level 3, Stockholm, 14:00 (English)
Harris, Robert, Associated Professor
Ståhl, Stefan, Professor