A three-dimensional ultrasonic cage for characterization of individual cells
2008 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 93, 063901- p.Article in journal (Refereed) Published
We demonstrate enrichment, controlled aggregation, and manipulation of microparticles and cells by an ultrasonic cage integrated in a microfluidic chip compatible with high-resolution optical microscopy. The cage is designed as a dual-frequency resonant filleted square box integrated in the fluid channel. Individual particles may be trapped three dimensionally, and the dimensionality of one-dimensional to three-dimensional aggregates can be controlled. We investigate the dependence of the shape and position of a microparticle aggregate on the actuation voltages and aggregate size, and demonstrate optical monitoring of individually trapped live cells with submicrometer resolution.
Place, publisher, year, edition, pages
2008. Vol. 93, 063901- p.
optical manipulation; microfluidic chip; particles; traps
Condensed Matter Physics
IdentifiersURN: urn:nbn:se:kth:diva-10916DOI: 10.1063/1.2971030ISI: 000258491000076ScopusID: 2-s2.0-49749149572OAI: oai:DiVA.org:kth-10916DiVA: diva2:231812
QC 201007302009-08-182009-08-182010-12-06Bibliographically approved