Flow-free transport of cells in microchannels by frequency-modulated ultrasound
2009 (English)In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 9, 833-837 p.Article in journal (Refereed) Published
We demonstrate flow-free transport of cells and particles by the use of frequency-modulated ultrasonic actuation of a microfluidic chip. Two different modulation schemes are combined: A rapid (1 kHz) linear frequency sweep around similar to 6.9 MHz is used for two-dimensional spatial stabilization of the force field over a 5 mm long inlet channel of constant cross section, and a slow (0.2-0.7 Hz) linear frequency sweep around similar to 2.6 MHz is used for flow-free ultrasonic transport and positioning of cells or particles. The method is used for controlling the motion and position of cells monitored with high-resolution optical microscopy, but can also be used more generally for improving the robustness and performance of ultrasonic manipulation micro-devices.
Place, publisher, year, edition, pages
2009. Vol. 9, 833-837 p.
manipulation; particles; chip; separation; channels
Condensed Matter Physics
IdentifiersURN: urn:nbn:se:kth:diva-10918DOI: 10.1039/B816675GISI: 000263847000012ScopusID: 2-s2.0-61849133822OAI: oai:DiVA.org:kth-10918DiVA: diva2:231814
QC 201007302009-08-182009-08-182010-12-06Bibliographically approved