Multidimensional Ultrasonic Standing Wave Manipulation in Microfluidic Chips
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
The use of ultrasonic standing waves for contactless manipulation of microparticles in microfluidic systems is a field with potential to become a new standard tool in lab-on-chip systems. Compared to other contactless manipulation methods ultrasonic standing wave manipulation shows promises of gentle cell handling, low cost, and precise temperature control. The technology can be used both for batch handling, such as sorting and aggregation, and handling of single particles.
This doctoral Thesis presents multi-dimensional ultrasonic manipulation, i.e., manipulation in both two and three spatial dimensions as well as time-dependent manipulation of living cells and microbeads in microfluidic systems. The lab-on-chip structures used allow for high-quality optical microscopy, which is central to many bio-applications. It is demonstrated how the ultrasonic force fields can be spatially confined to predefined regions in the system, enabling sequential manipulation functions. Furthermore, it is shown how frequency-modulated signals can be used both for spatial stabilization of the force fields as well as for flow-free transport of particles in a microchannel. Design parameters of the chip-transducer systems employed are investigated experimentally as well as by numerical simulations. It is shown that three-dimensional resonances in the solid structure of the chip strongly influences the resonance shaping in the channel.
Place, publisher, year, edition, pages
Stockholm: KTH , 2009. , ix, 83 p.
Trita-FYS, ISSN 0280-316X ; 2009:44
Condensed Matter Physics
IdentifiersURN: urn:nbn:se:kth:diva-10919ISBN: 978-91-7415-398-9OAI: oai:DiVA.org:kth-10919DiVA: diva2:231815
2009-09-11, FD5, Roslagstullsbacken 21, Stockholm, 14:00 (English)
Dual, Jürg, Prof.
Hertz, Hans M., Prof.Wiklund, Martin, PhD
QC 201007302009-09-012009-08-182010-07-30Bibliographically approved
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