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Smooth Muscle Modeling: Activation and contraction of contractile units in smooth muscle
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2009 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: KTH , 2009. , 14 p.
Series
Trita-HFL. Report / Royal Institute of Technology, Solid Mechanics, ISSN 1654-1472 ; 0475
Keyword [en]
muscle, modeling, contraction, activation, phosphorylation, artery, bladder
National Category
Applied Mechanics
Identifiers
URN: urn:nbn:se:kth:diva-11349OAI: oai:DiVA.org:kth-11349DiVA: diva2:274350
Presentation
2009-10-23, 10:00 (English)
Opponent
Supervisors
Available from: 2009-10-28 Created: 2009-10-28 Last updated: 2013-01-15Bibliographically approved
List of papers
1. A calcium-driven mechanochemical model for prediction of force generation in smooth muscle
Open this publication in new window or tab >>A calcium-driven mechanochemical model for prediction of force generation in smooth muscle
2010 (English)In: Biomechanics and Modeling in Mechanobiology, ISSN 1617-7959, E-ISSN 1617-7940, Vol. 9, no 6, 749-762 p.Article in journal (Refereed) Published
Abstract [en]

A new model for the mechanochemical response of smooth muscle is presented. The focus is on the response of the actin-myosin complex and on the related generation of force (or stress). The chemical (kinetic) model describes the cross-bridge interactions with the thin filament in which the calcium-dependent myosin phosphorylation is the only regulatory mechanism. The new mechanical model is based on Hill's three-component model and it includes one internal state variable that describes the contraction/relaxation of the contractile units. It is characterized by a strain-energy function and an evolution law incorporating only a few material parameters with clear physical meaning. The proposed model satisfies the second law of thermodynamics. The results of the combined coupled model are broadly consistent with isometric and isotonic experiments on smooth muscle tissue. The simulations suggest that the matrix in which the actin-myosin complex is embedded does have a viscous property. It is straightforward for implementation into a finite element program in order to solve more complex boundary-value problems such as the control of short-term changes in lumen diameter of arteries due to mechanochemical signals.

Keyword
Biomechanics, Calcium, Kinetic model, Mechanical model, Mechanochemical, Smooth muscle contraction
National Category
Applied Mechanics
Identifiers
urn:nbn:se:kth:diva-25400 (URN)10.1007/s10237-010-0211-0 (DOI)000284518200008 ()2-s2.0-78049334279 (Scopus ID)
Funder
Swedish Research Council, 2005-6167
Note
QC 20101020Available from: 2010-10-20 Created: 2010-10-20 Last updated: 2017-12-12Bibliographically approved
2. Modeling the dispersion effects of contractile fibers in smooth muscles
Open this publication in new window or tab >>Modeling the dispersion effects of contractile fibers in smooth muscles
2010 (English)In: Journal of the mechanics and physics of solids, ISSN 0022-5096, E-ISSN 1873-4782, Vol. 58, no 12, 2065-2082 p.Article in journal (Refereed) Published
Abstract [en]

Micro-structurally based models for smooth muscle contraction are crucial for a better understanding of pathological conditions such as atherosclerosis, incontinence and asthma. It is meaningful that models consider the underlying mechanical structure and the biochemical activation. Hence, a simple mechanochemical model is proposed that includes the dispersion of the orientation of smooth muscle myofilaments and that is capable to capture available experimental data on smooth muscle contraction. This allows a refined study of the effects of myofilament dispersion on the smooth muscle contraction. A classical biochemical model is used to describe the cross-bridge interactions with the thin filament in smooth muscles in which calcium-dependent myosin phosphorylation is the only regulatory mechanism. A novel mechanical model considers the dispersion of the contractile fiber orientations in smooth muscle cells by means of a strain-energy function in terms of one dispersion parameter. All model parameters have a biophysical meaning and may be estimated through comparisons with experimental data. The contraction of the middle layer of a carotid artery is studied numerically. Using a tube the relationships between the internal pressure and the stretches are investigated as functions of the dispersion parameter, which implies a strong influence of the orientation of smooth muscle myofilaments on the contraction response. It is straightforward to implement this model in a finite element code to better analyze more complex boundary-value problems.

Keyword
Artery, Biomechanics, Calcium, Dispersion, Smooth muscle contraction
National Category
Applied Mechanics
Identifiers
urn:nbn:se:kth:diva-25401 (URN)10.1016/j.jmps.2010.09.003 (DOI)000284568900005 ()2-s2.0-78049337618 (Scopus ID)
Note
QC 20101020Available from: 2010-10-20 Created: 2010-10-20 Last updated: 2017-12-12Bibliographically approved

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