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Ultrasound-based 2D Strain Estimation of the Carotid Artery: an in-silico feasibility study
KTH, School of Technology and Health (STH), Medical Engineering. (Skolan för teknik och hälsa)ORCID iD: 0000-0002-5795-9867
KTH, School of Technology and Health (STH), Medical Engineering.
2009 (English)In: Ultrasonics Symposium (IUS), 2009 IEEE International, IEEE , 2009, , 4 p.5441992- p.Conference paper, Published paper (Refereed)
Abstract [en]

Ultrasound based estimation of arterial wall properties is commonly used to assess vessel wall stiffness in studies of vascular diseases. Recently, it was shown that the longitudinal motion of the vessel during systole can be measured using speckle tracking. However, the assessment of longitudinal strain in the vessel wall has to be further investigated. The aim of this study was to test the feasibility of simultaneous assessment of radial and longitudinal strain in the carotid artery using computer simulations. A kinematic cylindrical model of the carotid artery with realistic dimensions was constructed. The model was deformed radially according to temporal distention measured in-vivo while longitudinal deformation was the result of conservation of volume. Moreover, longitudinal motion was superimposed based on profiles obtained in-vivo. Ultrasound long axis images were simulated using a generalized convolution model (COLE) with realistic image properties. Four models with different scatterer distributions were built. For each of them, longitudinal and radial motion were estimated using normalized cross-correlation with spline interpolation to detect sub-sample motion. Radial and longitudinal strains, obtained by linear regression were compared with the ground truth from the model. The maximal systolic radial strain was estimated to be -12.77 ± 0.4% (ground truth -13.89%) while longitudinal strain was 5.21 ± 0.67% (ground truth 5.3%). This study shows the feasibility of simultaneously measuring radial and longitudinal strain in the carotid artery by making use of currently available hardware.

Place, publisher, year, edition, pages
IEEE , 2009. , 4 p.5441992- p.
Series
Proceedings of the IEEE Ultrasonics Symposium, ISSN 1051-0117 ; 2009
Keyword [en]
Carotid artery, Strain imaging, Ultrasound
National Category
Industrial Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-11759DOI: 10.1109/ULTSYM.2009.5441992Scopus ID: 2-s2.0-77952790716ISBN: 978-142444389-5 (print)OAI: oai:DiVA.org:kth-11759DiVA: diva2:280835
Conference
2009 IEEE International Ultrasonics Symposium, IUS 2009; Rome; 20 September 2009 through 23 September 2009
Note
QC 20100727Available from: 2009-12-11 Created: 2009-12-11 Last updated: 2012-01-13Bibliographically approved
In thesis
1. Quantification and Visualization of Cardiovascular Function using Ultrasound
Open this publication in new window or tab >>Quantification and Visualization of Cardiovascular Function using Ultrasound
2009 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

There is a large need for accurate methods detecting cardiovascular diseases, since they are one of the leading causes of mortality in the world, accounting for 29.3% of all deaths. Due to the complexity of the cardiovascular system, it is very challenging to develop methods for quantification of its function in order to diagnose, prevent and treat cardiovascular diseases. Ultrasound is a technique allowing for inexpensive, noninvasive imaging, but requires an experienced echocardiographer. Nowadays, methods like Tissue Doppler imaging (TDI) and Speckle tracking imaging (STI), measuring motion and deformation in the myocardium and the vessel walls, are getting more common in routine clinical practice, but without a proper visualization of the data provided by these methods, they are time-consuming and difficult to interpret. Thus, the general aim of this thesis was to develop novel ultrasound-based methods for accurate quantification and easily interpretable visualization of cardiovascular function.

Five methods based on TDI and STI were developed in the present studies. The first study comprised development of a method for generation of bull’s-eye plots providing a color-coded two-dimensional visualization of myocardial longitudinal velocities. The second study proposed the state diagram of the heart as a new circular visualization tool for cardiac mechanics, including segmental color-coding of cardiac time intervals. The third study included development of a method describing the rotation pattern of the left ventricle by calculating rotation axes at different levels of the left ventricle throughout the cardiac cycle. In the fourth study, deformation data from the artery wall were tested as input to wave intensity analysis providing information of the ventricular – arterial interaction. The fifth study included an in-silico feasibility study to test the assessment of both radial and longitudinal strain in a kinematic model of the carotid artery.

The studies showed promising results indicating that the methods have potential for the detection of different cardiovascular diseases and are feasible for use in the clinical setting. However, further development of the methods and both quantitative comparison of user dependency, accuracy and ease of use with other established methods evaluating cardiovascular function, as well as additional testing of the clinical potential in larger study populations, are needed.

Place, publisher, year, edition, pages
Stockholm: KTH, 2009. x, 72 p.
Series
Trita-STH : report, ISSN 1653-3836 ; 2009:6
Keyword
Ultrasound, Tissue Doppler imaging, Speckle tracking imaging, cardiovascular function, visualization, quantification
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:kth:diva-11762 (URN)978-91-7415-524-2 (ISBN)
Public defence
2010-01-22, 3-221, Alfred Nobels Alle 10, Huddinge, 08:30 (Swedish)
Opponent
Supervisors
Note
QC 20100727Available from: 2009-12-14 Created: 2009-12-11 Last updated: 2010-10-04Bibliographically approved

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