Polymer–drug interactions and wetting of solid dispersions
2009 (English)In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 39, no 1-3, 125-133 p.Article in journal (Refereed) Published
We demonstrate the ability of drugs to influence the wetting of solid dispersion tablets in unexpected ways. Five model drugs of different water solubility and ability to interact with the involved polymers were incorporated in hydrophilic polymer matrices, made of either hydroxypropyl methylcellulose (HPMC) or polyvinyl pyrrolidone (PVP). The physical mixtures of all combinations of drug and polymer presented surface hydrophobicities, as measured by the equilibrium advancing contact angle of water, which are expected for materials that do not influence the interactions of each other with water. However, the solid dispersions containing HPMC deviated from this regular behaviour and displayed contact angles below those of the pure compounds involved, either drug or polymer. This behaviour is explained by changed surface exposure of HPMC side groups, as a result of changes in intermolecular hydrogen bonds. In addition to water contact angle measurements, we employed NMR imaging to monitor the time course of water ingress and swelling.
Place, publisher, year, edition, pages
2009. Vol. 39, no 1-3, 125-133 p.
Contact angle, Hydrophilic matrices, Nuclear magnetic resonance imaging, Hydroxypropyl methylcellulose (HPMC), Polyvinyl pyrrolidone (PVP)
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:kth:diva-11787DOI: 10.1016/j.ejps.2009.11.005ISI: 000274672300018OAI: oai:DiVA.org:kth-11787DiVA: diva2:282112
FunderSwedish Research CouncilKnut and Alice Wallenberg Foundation
QC 201009152009-12-182009-12-182012-02-14Bibliographically approved