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A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips
KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).ORCID iD: 0000-0001-9008-8402
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2010 (English)In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 10, no 3, 281-290 p.Article in journal (Refereed) Published
Abstract [en]

We present the design, fabrication, and characterisation of an array of optical slot-waveguide ring resonator sensors, integrated with microfluidic sample handling in a compact cartridge, for multiplexed real-time label-free biosensing. Multiplexing not only enables high throughput, but also provides reference channels for drift compensation and control experiments. Our use of alignment tolerant surface gratings to couple light into the optical chip enables quick replacement of cartridges in the read-out instrument. Furthermore, our novel use of a dual surface-energy adhesive film to bond a hard plastic shell directly to the PDMS microfluidic network allows for fast and leak-tight assembly of compact cartridges with tightly spaced fluidic interconnects. The high sensitivity of the slot-waveguide resonators, combined with on-chip referencing and physical modelling, yields a volume refractive index detection limit of 5 x 10(-6) refractive index units (RIUs) and a surface mass density detection limit of 0.9 pg mm(-2), to our knowledge the best reported values for integrated planar ring resonators.

Place, publisher, year, edition, pages
2010. Vol. 10, no 3, 281-290 p.
Keyword [en]
MICRORING RESONATOR, SILICON, INTERFACE, BIOSENSOR, SYSTEMS
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-12208DOI: 10.1039/b914183aISI: 000273744700003Scopus ID: 2-s2.0-75149156504OAI: oai:DiVA.org:kth-12208DiVA: diva2:305946
Note

QC 20100715

Available from: 2010-03-25 Created: 2010-03-25 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Integrated Optical Slot-Waveguide Ring Resonator Sensor Arrays for Lab-on-Chip Applications
Open this publication in new window or tab >>Integrated Optical Slot-Waveguide Ring Resonator Sensor Arrays for Lab-on-Chip Applications
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis treats the development of an integrated optical sensor array. The sensors are slot-waveguide ring resonators, integrated with on-chip surface grating couplers and light splitters, for alignment tolerant, real-time, refractive index sensing, and label-free biosensing. The work includes: the design of components and system layouts, the development of fabrication methods, the fabrication of sensor chips, the characterization of the chips, and the development of physical system models for accurate extraction of resonance wavelengths in measured spectra.

The main scientific achievements include: The evaluation of a novel type of nano-structured optical waveguide for biochemical sensing. The realization of an array of such slot-waveguide sensors, integrated with microfluidic sample handling, for multiplex assays. The first study of the thermal behavior of slot-waveguide sensors and the discovery of unique temperature compensation capabilities.

From an application perspective, the use of alignment tolerant surface gratings to couple light into the optical chip enables quick replacement of cartridges in the read-out instrument. Furthermore, the fabrication sequence avoids polishing of individual chips, and thus ensures that the cost benefits of silicon batch micro-fabrication can be leveraged in mass production.

The high sensitivity of the slot waveguide resonators, combined with on-chip referencing and physical modeling, yields low limits of detection. The obtained volume refractive index detection limit of 5 × 10−6 refractive index units (RIU), and the surface mass density detection limit of 0.9 pg/mm2, shows that performance comparable to that of commercial non-integrated surface plasmon resonance sensors, made from bulk optical components, canbe achieved in a compact cartridge.

Place, publisher, year, edition, pages
Stockholm: KTH, 2010. xvii, 98 p.
Series
Trita-EE, ISSN 1653-5146
Keyword
biosensor, label-free biosensing, ring resonator, optical waveguide, lab-on-a-chip
National Category
Control Engineering Telecommunications
Identifiers
urn:nbn:se:kth:diva-12214 (URN)978-91-7415-594-5 (ISBN)
Public defence
2010-04-16, F3, Lindstedtsvägen 26, KTH, Stockholm, 10:15 (English)
Opponent
Supervisors
Projects
SABIO
Note
Qc20100715Available from: 2010-04-06 Created: 2010-03-25 Last updated: 2010-07-15Bibliographically approved
2. Development of materials, surfaces and manufacturing methods for microfluidic applications
Open this publication in new window or tab >>Development of materials, surfaces and manufacturing methods for microfluidic applications
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis presents technological advancements in microfluidics. The overall goals of the work are to develop new miniaturized tests for point-of-care diagnostics and robust super-lubricating surfaces for friction reduction. To achieve these goals, novel materials, surfaces and manufacturing methods in microfluidics have been developed.

Point-of-care diagnostic tests are portable miniaturized instruments that downscale and automate medical tests previously performed in the central laboratories of hospitals. The instruments are used in the doctor’s office, in the emergency room or at home as self-tests. By bringing the analysis closer to the patient, the likelihood of an accurate diagnosis, or a quick therapy adjustment is increased. Already today, there are point-of-care tests available on the market, for example blood glucose tests, rapid streptococcus tests and pregnancy tests. However, for more advanced diagnostic tests, such as DNA-tests or antibody analysis, integration of microfluidic functions for mass transport and sample preparation is required. The problem is that the polymer materials used in academic development are not always suited for prototyping microfluidic components for sensitive biosensors. Despite the enormous work that has gone into the field, very few technical solutions have been implemented commercially.

The first part of the work deals with the development of prototype point of-care tests. The research has focused on two major areas: developing new manufacturing methods to leverage the performance of existing materials and developing a novel polymer material platform, adapted for the extreme demands on surfaces and materials in miniaturized laboratories. The novel manufacturing methods allow complex 3D channel networks and the integration of materials with different surface properties. The novel material platform is based on a novel off-stoichiometry formulation of thiol-enes (OSTE) and has very attractive material and manufacturing properties from a lab-on-chip perspective, such as, chemically stable surfaces, low absorption of small molecules, facile and inexpensive manufacturing process and a biocompatible bonding method. As the OSTE-platform can mirror many of the properties of commercially used polymers, while at the same time having an inexpensive and facile manufacturing method, it has potential to bridge the gap between research and commercial production.

Friction in liquid flows is a critical limiting factor in microfluidics, where friction is the dominant force, but also in marine applications where frictional losses are responsible for a large part of the total energy consumption of sea vessels. Microstructured surfaces can drastically reduce the frictional losses by trapping a layer of air bubbles on the surface that can act as an air bearing for the liquid flow. The problem is that these trapped air bubbles collapse at the liquid pressures encountered in practical applications.

The last part of the thesis is devoted to the development of novel low fluidfriction surfaces with increased robustness but also with active control of the surface friction. The results show that the novel surfaces can resist up to three times higher liquid pressure than previous designs, while keeping the same friction reducing capacity. The novel designs represent the first step towards practical implementation of micro-structured surfaces for friction reduction.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2011. xiii, 87 p.
Series
Trita-EE, ISSN 1653-5146 ; 2011:058
Keyword
microsystem technology, MEMS, microfluidics, polymers, off-stoichiometry thiol-ene, point-of-care, lab-on-chip
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:kth:diva-38605 (URN)978-91-7501-086-1 (ISBN)
Public defence
2011-09-23, F3, Lindstedtsvägen 26, KTH, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20110907

Available from: 2011-09-02 Created: 2011-08-30 Last updated: 2012-09-03Bibliographically approved

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Gylfason, Kristinn BjörgvinSohlström, HansStemme, Göranvan der Wijngaart, Wouter

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Carlborg, Carl FredrikGylfason, Kristinn BjörgvinSohlström, HansMoh, ThomasStemme, Göranvan der Wijngaart, Wouter
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