Direct STD NMR Identification of beta-Galactosidase Inhibitors from a Virtual Dynamic Hemithioacetal System
2010 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 49, no 3, 589-593 p.Article in journal (Refereed) Published
The formation of a dynamic hemithioacetal system and its application toward the discovery of ß-galactosidase inhibitors were successfully investigated. The designed dynamic system, which has a virtual character in neutral aqueous media, was subjected to a direct in situ identification of the best inhibitors by 1H STD NMR spectroscopy (ONPC : o-nitrophenyl-β-galactopyranoside).
Place, publisher, year, edition, pages
2010. Vol. 49, no 3, 589-593 p.
beta-galactosidase, dynamic chemistry, hemithioacetals, inhibition, NMR spectroscopy, NUCLEAR-MAGNETIC-RESONANCE, COMBINATORIAL LIBRARIES, ESCHERICHIA-COLI, LIGAND-BINDING, LIVING CELLS, ACTIVE-SITE, CHEMISTRY, SPECTROSCOPY, RECEPTORS, PROTEIN
IdentifiersURN: urn:nbn:se:kth:diva-12442DOI: 10.1002/anie.200903920ISI: 000274262800023ScopusID: 2-s2.0-74549200492OAI: oai:DiVA.org:kth-12442DiVA: diva2:311714
FunderSwedish Research Council
QC 201009082010-04-222010-04-222011-01-24Bibliographically approved