High quality and tuneable silica shell-magnetic core nanoparticles
2010 (English)In: Journal of nanoparticle research, ISSN 1388-0764, E-ISSN 1572-896X, Vol. 12, no 4, 1137-1147 p.Article in journal (Refereed) Published
Obtaining small (<50 nm), monodispersed, well-separated, single iron oxide core-silica SiO2) shell nanoparticles for biomedical applications is still a challenge. Preferably, they are synthesized by inverse microemulsion method. However, substantial amount of aggregated and multicore core- shell nanoparticles is the undesired outcome of the method. In this study, we report on the production of less than 50 nm overall size, monodispersed, free of necking, single core iron oxide-SiO2 shell nanoparticles with tuneable shell thickness by a carefully optimized inverse microemulsion method. The high degree of control over the process is achieved by understanding the mechanism of core-shell nanoparticles formation. By varying the reaction time and recursor concentration, the thickness of silica layer an the core nanoparticles can be finely adjusted from to 13 nm. Residual reactions during the workup were inhibited by a combination of pH control with hock freezing and ultracentrifuging. These highquality tuneable core-shell nanocomposite particles exhibit superparamagnetic character and sufficiently high magnetization with great potential for biomedical applications (e.g. MRI, cell separation and magnetically driven drug delivery systems) either as-prepared or by additional surface modification for improved biocompatibility.
Place, publisher, year, edition, pages
2010. Vol. 12, no 4, 1137-1147 p.
Core-shell, Inverse microemulsion, Nanomedicine, Nanoparticle, Non-aggregated, Silica, Superparamagnetism
Social Sciences Interdisciplinary
IdentifiersURN: urn:nbn:se:kth:diva-12703DOI: 10.1007/s11051-009-9661-7ISI: 000276883600007ScopusID: 2-s2.0-77955086109OAI: oai:DiVA.org:kth-12703DiVA: diva2:318128
FunderEU, FP7, Seventh Framework ProgrammeKnut and Alice Wallenberg Foundation, UAW2004.0224
QC 201104152010-05-062010-05-062011-04-15Bibliographically approved