Crystallization-induced secondary selection from a tandem driven dynamic combinatorial resolution process
2008 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 73, no 9, 3593-3595 p.Article in journal (Refereed) Published
Crystallization-induced secondary selection from a tandem driven dynamic combinatorial library is presented. In a one-pot experiment, an initial nitroaldol equilibrium was kinetically driven by a tandem reaction resulting in a subsequent dynamic library of diastereoisomers. This library was then further driven by a phase change, resulting in amplification and isolation of a highly diastereomerically enriched and synthetically interesting isoindolinone.
Place, publisher, year, edition, pages
2008. Vol. 73, no 9, 3593-3595 p.
ASYMMETRIC-SYNTHESIS, DRUG DISCOVERY, SOLID-STATE, CHEMISTRY, LIBRARIES, REARRANGEMENT, LIGANDS
IdentifiersURN: urn:nbn:se:kth:diva-12713DOI: 10.1021/jog002453ISI: 000255339600042ScopusID: 2-s2.0-43449087343OAI: oai:DiVA.org:kth-12713DiVA: diva2:318259
QC 201005072010-05-072010-05-072011-05-06Bibliographically approved