Tandem reversible addition-intramolecular lactonization for the synthesis of 3-functionalized phthalides
2010 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 51, no 1, 75-78 p.Article in journal (Refereed) Published
A new tandem process based on reversible nucleophilic addition and intramolecular lactonization of methyl 2-formylbenzoate leads to the efficient synthesis of 3-functionalized phthalides, which are important precursors for the synthesis of quinone skeletons via Hauser–Kraus annulation. The reactions are successfully carried out under mild conditions in single operations.
Place, publisher, year, edition, pages
2010. Vol. 51, no 1, 75-78 p.
DYNAMIC COMBINATORIAL RESOLUTION, ANNULATION REACTIONS, CHEMISTRY, ANNELATION
IdentifiersURN: urn:nbn:se:kth:diva-12736DOI: 10.1016/j.tetlet.2009.10.079ISI: 000274232200018ScopusID: 2-s2.0-70649083235OAI: oai:DiVA.org:kth-12736DiVA: diva2:318438
FunderSwedish Research Council
QC 201101262010-05-072010-05-072011-05-26Bibliographically approved