Self-adaptable Catalysts: Substrate-Dependent Ligand Configuration
2008 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 130, no 6, 1845-1855 p.Article in journal (Refereed) Published
Pd(II) allyl and Pd(0) olefin complexes containing the configurationally labile ligand 1,2-bis-[4,5dihydro-3H-dibenzo[c-e]azepino]ethane were studied as models for intermediates in Pd-catalyzed allylic alkylations. According to NMR and DFT studies, the ligand prefers C-s conformation in both eta(3)-1,3-diphenylpropenyl and eta(3)-cyclohexenyl Pd(II) complexes, whereas in Pd(0) olefin complexes it adopts different conformations in complexes derived from the two types of allyl systems in both solution and, as verified by X-ray crystallography, in the solid state. These results demonstrate that the Pd complex is capable of adapting its structure to the reacting substrate. The different structural preferences also provide an explanation for the behavior of 1,3-diphenyl-2-propenyl acetate and 2-cyclohexenyl acetate in Pd-catalyzed allylic alkylations using pseudo-C-2 and pseudo-C-s symmetric ligands.
Place, publisher, year, edition, pages
Washington DC: American Chemical Society , 2008. Vol. 130, no 6, 1845-1855 p.
adaptable, flexible, phosphepine, azepine, Pd complex, DFT calculations, ligand design, chiral shift reagent, symmetry, X-ray chrystallography
IdentifiersURN: urn:nbn:se:kth:diva-12851DOI: 10.1021/ja074044kISI: 000253100200022ScopusID: 2-s2.0-39049140882OAI: oai:DiVA.org:kth-12851DiVA: diva2:319276