Novel drug delivery microspheres from poly(1,5-dioxepan-2-one-co-L-lactide)
1999 (English)In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 37, no 12, 1877-1884 p.Article in journal (Refereed) Published
Novel microspheres from copolymers of 1,5-dioxepan-2-one (DXO) and L-lactide (L-LA) were prepared by oil-in-water solvent evaporation and oil-in-oil solvent removal. The two preparation techniques were evaluated for sphere formulation and incorporation of two different drugs. Sustained release of these therapeutic substances was obtained. The consequences of altering the DXO : LA ratio, preparation method, and drug hydrophilicity were explored and identified as factors governing sphere quality, in vitro degradation, and drug release characteristics. We show that these relationships provide a powerful means of controlling the microsphere performance.
Place, publisher, year, edition, pages
1999. Vol. 37, no 12, 1877-1884 p.
1, 5-dioxepan-2-one, L-lactic acid, microspheres, drug delivery, controlled release, RELEASE
IdentifiersURN: urn:nbn:se:kth:diva-13120ISI: 000080345100017OAI: oai:DiVA.org:kth-13120DiVA: diva2:321004
QC 201005282010-05-282010-05-282010-05-28Bibliographically approved