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Well-organized phase-separated nanostructured surfaces of hydrophilic/hydrophobic ABA triblock copolymers
KTH, Superseded Departments, Polymer Technology.ORCID iD: 0000-0002-1922-128X
KTH, Superseded Departments, Polymer Technology.
KTH, Superseded Departments, Polymer Technology.
2003 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 4, no 5, 1451-1456 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2003. Vol. 4, no 5, 1451-1456 p.
Keyword [en]
ATOMIC-FORCE MICROSCOPY, L-LACTIDE, THIN-FILM, 1, 5-DIOXEPAN-2-ONE, POLY(L-LACTIDE), NANOTOPOGRAPHY, MORPHOLOGIES, CELLS
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-13190DOI: 10.1021/bm0341024ISI: 000185386900047OAI: oai:DiVA.org:kth-13190DiVA: diva2:321699
Note
QC 20100602Available from: 2010-06-02 Created: 2010-06-02 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Novel Possibilities for Advanced Molecular Structure Design for Polymers and Networks
Open this publication in new window or tab >>Novel Possibilities for Advanced Molecular Structure Design for Polymers and Networks
2003 (English)Doctoral thesis, comprehensive summary (Other scientific)
Abstract [en]

Synthetic and degradable polymers are an attractive choicein many areas, since it is possible to control the way in whichthey are manufactured; more specifically, pathways tomanipulate the architecture, the mechanical properties and thedegradation times have been identified. In this work,L-lactide, 1,5-dioxepan-2-one and ε-caprolactone were usedas monomers to synthesize polymers with different architecturesby ring-opening polymerization. By using novel initiators,triblock copolymers, functionalized linear macromonomers andstar-shaped aliphatic polyesters with well-defined structureshave been synthesized. To synthesize triblock copolymers,cyclic germanium initiators were studied. The polymerizationproceeded in a controlled manner although the reaction rateswere low. To introduce functionality into the polymer backbone,functionalized cyclic tin alkoxides were prepared and used asinitiators. During the insertion-coordination polymerization,the initiator fragment consisting mainly of a double bond wasincorporated into the polymer backbone. The double bond wasalso successfully epoxidized and this gave unique possibilitiesof synthesizing graft polymers with precise spacing. Themacromonomer technique is a very effective method for producingwell-defined graft polymers. Spirocyclic tin initiators weresynthesized and used to construct star-shaped polymers. Thestar-shaped polymers were subsequently crosslinked in apolycondensation reaction. These crosslinked structures swelledin water, and swelling tests showed that by changing thestructure of the hydrogel network, the degree of swelling canbe altered. A first evaluation of the surface characteristicsof the linear triblock copolymers was also performed. AFManalysis of the heat-treated surfaces revealed nanometer-scalefibers and tests showed that keratinocytes were able to growand proliferate on these surfaces.

Place, publisher, year, edition, pages
Stockholm: KTH, 2003. 78 p.
Keyword
ring-opening polymerization, coordination-insertion, germanium, cyclic tin alkoxides, spirocyclic initiators, poly(L-lactide), poly(1, 5-dioxepan-2-one), triblock, star-shaped, network, functionalization, morphology, AFM
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:kth:diva-3623 (URN)91-7283-577-X (ISBN)
Public defence
2003-10-31, 00:00 (English)
Note
QC 20100602Available from: 2003-10-28 Created: 2003-10-28 Last updated: 2010-06-02Bibliographically approved
2. Bioresorbable copolymers with tailored properies: innovative materials för soft tissuel engineering
Open this publication in new window or tab >>Bioresorbable copolymers with tailored properies: innovative materials för soft tissuel engineering
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The emerging need for new synthetic materials for soft tissue engineering applications encourages the search for innovative polymers having interesting properties. Ring-opening polymerization of lactones and lactides initiated by tin alkoxides has received particular attention due to the versatility of the method for building up well-defined biodegradable structures. The controlled reactions together with a careful choice of comonomers and copolymer composition make it possible to create materials with desired molecular architecture and properties.The aim of the work described in this thesis was to design aliphatic bioresorbable copolymers with new structures and controlled properties for potential application in soft tissue engineering. The first part of the work was focused on the surface properties of the materials synthesized for biomedical application. Solution-cast film triblock copolymers of L-lactide (LLA) and 1,5-dioxepan-2-one (DXO), subjected to thermal treatment have been studied. The effects of molecular weight, polymer composition, cooling rate, and casting solution concentration on the nanostructure surface morphology and topography have been investigated by atomic force microscopy (AFM). The surface characterization of the annealed triblock copolymers revealed well-defined fiber features formed as a result of a melt-induced micro-phase separation during crystallization. The dimensions and shape of the formations could be related to the copolymer composition and annealing conditions, and this makes it possible to create controlled and well-defined surface structure. The results of cell adhesion studies on annealed triblock copolymers indicate that these materials favor fibroblast growth and spreading, which makes them promising candidates for applications as bioresorbable membranes.In the next stage of the work, linear and network copolymers of ε-caprolactone (CL) and DXO with a controlled composition and controlled hydrophilicity have been synthesized. The molar fraction of DXO in the copolymers affected their mechanical, thermal and surface properties. The hydrophilicity was tailored by changing the monomer composition in the copolymers. The AFM measurements on the linear copolymers showed that short fibrillar structures were formed upon crystallization from the melt. The supple CL-DXO networks were easy to cast and could easily be removed from the mould surface, so that it is possible to use this material for embossing procedures without the risk of damaging the surface pattern during removal from the mould.

Place, publisher, year, edition, pages
Stockholm: KTH, 2006. 70 p.
Series
Trita-FPT-Report, ISSN 1652-2443 ; 2006:18
Keyword
poly(1, 5-dioxepan-2-one), poly(ε-caprolactone), poly(L-lactide), poly(trimethylene carbonate), triblock, network, cyclic tin alkoxide, controlled coordination-insertion ring-opening polymerization, thermoplastic elastomers
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:kth:diva-4042 (URN)91-7178-378-4 (ISBN)
Public defence
2006-06-16, Aal K2, Teknikringen 28, Stockholm, 10:00 (English)
Opponent
Supervisors
Note
QC 20100629Available from: 2006-06-07 Created: 2006-06-07 Last updated: 2010-06-29Bibliographically approved

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