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The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.
KTH, Superseded Departments, Biotechnology.ORCID iD: 0000-0003-0996-1644
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1996 (English)In: European Journal of Biochemistry, ISSN 0014-2956, E-ISSN 1432-1033, Vol. 238, no 2, 325-32 p.Article in journal (Refereed) Published
Abstract [en]

The peptide FA-LL-37, previously termed FALL-39, was originally predicted from on ORF of a cDNA clone isolated from a human bone marrow library. This peptide was synthesized and found to have antibacterial activity. We have now characterized and sequenced the complete gene for FA-LL-37, termed FALL39. It is a compact gene of 1963 bp with four exons. Exons 1-3 code for a signal sequence and the cathelin region. Exon 4 contains the information for the mature antibacterial peptide. Our results indicate that FALL39 is the only member of the cathelin gene family present in the human genome. Potential binding sites for acute-phase-response factors are identified in the promoter and in intron 2. A possible role for the cytokine interleukin-6 in the regulation of FALL 39 is discussed. Anti-(FA-LL-37) IgG located the peptide in granulocytes and we isolated the mature peptide from these cells after degranulation. Structural analysis determined the mature peptide to be LL-37. To obtain LL-37 for antibacterial assays, synthetic FA-LL-37 was degraded with dipeptidyl-peptidase I. This analysis showed that mature LL-37 is a potent antibacterial peptide.

Place, publisher, year, edition, pages
1996. Vol. 238, no 2, 325-32 p.
National Category
Industrial Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-13360PubMedID: 8681941OAI: oai:DiVA.org:kth-13360DiVA: diva2:324517
Note
QC 20100615Available from: 2010-06-15 Created: 2010-06-15 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Analysis of human gene transcripts: Identification and characterisation based on homology and differential expression
Open this publication in new window or tab >>Analysis of human gene transcripts: Identification and characterisation based on homology and differential expression
1998 (English)Doctoral thesis, comprehensive summary (Other scientific)
Place, publisher, year, edition, pages
Stockholm: KTH, 1998. 68 p.
National Category
Industrial Biotechnology
Identifiers
urn:nbn:se:kth:diva-2751 (URN)91-7170-347-0 (ISBN)
Public defence
1998-12-18, 00:00
Note
QC 20100615Available from: 2000-01-01 Created: 2000-01-01 Last updated: 2010-06-17Bibliographically approved

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