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Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population
KTH, Superseded Departments, Biochemistry and Biotechnology.ORCID iD: 0000-0002-1495-8338
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1996 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 93, no 21, 12035-12039 p.Article in journal (Refereed) Published
Abstract [en]

An analysis of Y-chromosomal haplotypes in several European populations reveals an almost monomorphic pattern in the Finns, whereas Y-chromosomal diversity is significantly higher in other populations. Furthermore, analyses of nucleotide positions in the mitochondrial control region that evolve slowly show a decrease in genetic diversity in Finns. Thus, relatively few men and women have contributed the genetic lineages that today survive in the Finnish population. This is likely to have caused the so-called ''Finnish disease heritage''-i.e., the occurrence of several genetic diseases in the Finnish population that are rare elsewhere. A preliminary analysis of the mitochondrial mutations that have accumulated subsequent to the bottleneck suggests that it occurred about 4000 years ago, presumably when populations using agriculture and animal husbandry arrived in Finland.

Place, publisher, year, edition, pages
1996. Vol. 93, no 21, 12035-12039 p.
Keyword [en]
HUMAN MITOCHONDRIAL-DNA, Y-CHROMOSOME, EVOLUTION, FINLAND, ASPARTYLGLUCOSAMINURIA, SEQUENCE, EUROPE, GENES
National Category
Social Sciences Interdisciplinary
Identifiers
URN: urn:nbn:se:kth:diva-13926ISI: A1996VM68100132OAI: oai:DiVA.org:kth-13926DiVA: diva2:328273
Note
20100702Available from: 2010-07-02 Created: 2010-07-02 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Mitochondrial DNA: analysis of the control region in forensic and population genetic studies
Open this publication in new window or tab >>Mitochondrial DNA: analysis of the control region in forensic and population genetic studies
1999 (English)Doctoral thesis, comprehensive summary (Other scientific)
Place, publisher, year, edition, pages
Stockholm: KTH, 1999. 49 p.
Keyword
mitochondrial DNA, control region, tandem repeats, D-loop, homoplasmy, hair, forensic, microsatellites, evolution, DNA sequencing, PCR, domestic dog, wolf
National Category
Industrial Biotechnology
Identifiers
urn:nbn:se:kth:diva-2824 (URN)91-7170-408-6 (ISBN)
Public defence
1999-06-11, 00:00
Note
QC 20100702Available from: 2000-01-01 Created: 2000-01-01 Last updated: 2010-07-02Bibliographically approved

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Savolainen, Peter

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