MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear
2010 (English)In: Nanomedicine, ISSN 1743-5889, Vol. 5, no 5, 739-754 p.Article in journal (Refereed) Published
Aim: Superparamagnetic iron oxide nanoparticles hierarchically coated with oleic acid and Pluronic F127 copolymers (POA@SPION) have shown exceptional 12 contrast enhancement. The aim of the present work was to investigate the MRI manifestation of POA@SPION in the inner ear. Materials & methods: A total of 26 male Wister rats were selected for testing POA@SPION administered through intracochlear, intratympanic and intravenous routes. MRI was performed with a 4.7 T MR scanner. Results & conclusion: POA@SPION can be introduced into the perilymph space, after which it becomes widely distributed and can demonstrate the integrity of the perilymph-endolymph barrier. Positive highlighting of the endolymph compartment against the darkened perilymph was visualized for the first time. POA@SPION passed through the middle-inner ear barriers in only small amounts, but stayed in the perilymph for 3 days. They did not traverse the blood-perilymph barrier or blood-endolymph barrier. The inner ear distribution of POA@SPION was confirmed by histology. POA@SPION is a promising T2 negative contrast agent.
Place, publisher, year, edition, pages
2010. Vol. 5, no 5, 739-754 p.
animal, biological barrier, biomaterial, contrast agent inner ear fluids, MRI, nanoparticle, superparamagnetic iron oxide nanoparticles, tight junction
Medical Laboratory and Measurements Technologies
IdentifiersURN: urn:nbn:se:kth:diva-14166DOI: 10.2217/nnm.10.45ISI: 000280454400015PubMedID: 20662645ScopusID: 2-s2.0-77954918617OAI: oai:DiVA.org:kth-14166DiVA: diva2:331337
QC 20100722 Uppdaterad från submitted till published (20110211).2010-07-222010-07-222011-02-11Bibliographically approved