Change search
ReferencesLink to record
Permanent link

Direct link
Particle size distribution and evolution in tablet structure during and after compaction
KTH, School of Chemical Science and Engineering (CHE), Chemical Engineering and Technology, Transport Phenomena.
2005 (English)In: Internation Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 292, no 02-jan, 211-225 p.Article in journal (Refereed) Published
Abstract [en]

The objective of this study was to investigate the effect of the distribution in size of free-flowing particles for the evolution in tablet structure and tablet strength. For sucrose and sodium chloride, three powders of different size distributions were prepared by mixing predetermined quantities of particle size fractions. For paracetamol, three batches with varying particle size distributions were prepared by crystallisation. The powders were formed into tablets. Tablet porosity and tensile strength were determined directly after compaction and after short-term storage at two different relative humidities. Tablets were also formed after admixture of a lubricant (magnesium stearate) and the tablet tensile strength was determined. For the test materials used in this study, the spread in particle size had no influence on the evolution in tablet porosity and tensile strength during compression. However, the spread in particle size had a significant and complex influence on the short-term post-compaction increase in tablet tensile strength. The effect of the spread was related to the instability mechanism and the presence of lubricant. It is concluded that the distribution in size of free-flowing particles is not critical for the tablet porosity but may give significant effects on tablet tensile strength due to a post-compaction reaction.

Place, publisher, year, edition, pages
2005. Vol. 292, no 02-jan, 211-225 p.
Keyword [en]
particle size distribution, tablet tensile strength, tablet porosity, storage, relative humidity, lubricant, direct compression, tensile-strength, paracetamol, fragmentation, storage, design, powder
URN: urn:nbn:se:kth:diva-14603DOI: 10.1016/j.ijpharm.2004.12.003ISI: 000227631500020ScopusID: 2-s2.0-13844297704OAI: diva2:332644
QC 20100525Available from: 2010-08-05 Created: 2010-08-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Rasmuson, Åke C.
By organisation
Transport Phenomena
In the same journal
Internation Journal of Pharmaceutics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 42 hits
ReferencesLink to record
Permanent link

Direct link