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4-aminophenylacetic acid
KTH, School of Chemical Science and Engineering (CHE), Chemical Engineering and Technology, Transport Phenomena.
KTH, School of Chemical Science and Engineering (CHE), Chemical Engineering and Technology, Transport Phenomena.ORCID iD: 0000-0002-6647-3308
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Inorganic Chemistry.
2005 (English)In: Acta Crystallographica Section E: Structure Reports Online, ISSN 1600-5368, E-ISSN 1600-5368, Vol. 61, no 6, O1536-O1537 p.Article in journal (Refereed) Published
Abstract [en]

Crystals of the title compound, C8H9NO2, were obtained from ethyl acetate. The structure consists of the acid in its zwitterionic form. In the crystal structure, each molecule interacts through strong N-H center dot center dot center dot O hydrogen bonds with six adjacent molecules, yielding a three-dimensional network.

Place, publisher, year, edition, pages
2005. Vol. 61, no 6, O1536-O1537 p.
National Category
Chemical Engineering
URN: urn:nbn:se:kth:diva-14785DOI: 10.1107/s1600536805012754ISI: 000229464500108ScopusID: 2-s2.0-32244447825OAI: diva2:332826
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2010-10-14Bibliographically approved
In thesis
1. Solubility and polymorphism of molecular compounds
Open this publication in new window or tab >>Solubility and polymorphism of molecular compounds
2005 (English)Doctoral thesis, comprehensive summary (Other scientific)
Abstract [en]

This thesis deals with the controlled crystallization of small organic molecules and is focused on solubility and polymorphism. The solubility was determined for phenylacetic acid, p-hydroxyphenylacetic acid, p-aminophenylacetic acid, p-hydroxybenzoic acid and ibuprofen in both water and in a range of organic solvents. Data is discussed from the standpoint of molecular aspects of solute – solvent interactions and by estimated solid phase activity. It was shown that better understanding could be acquired by making a qualitative analysis of the molecular interactions in the solution and the crystal structure of the compounds in question.

Solubility predictions that are carried out by the UNIFAC method are not sufficiently accurate to serve as a basis for a reliable design of a crystallization process or selection of a suitable solvent since they deviate more than 15% from experimental values. The reason for the discrepancies are related to uncertainties in the prediction of activity coefficients by UNIFAC, as well as, difficulties in the estimation of the activity of the solid state.

p-Aminobenzoic acid (PABA) has been crystallized from thirteen different solvents either by slow cooling, after which the product is allowed to mature in suspension, or by rapid cooling followed by immediate isolation. Two different polymorphs have been crystallized. The system is found to be enantiotropic with the transition temperature of 25 °C, below which the β-form is the stable polymorph. The α-form was obtained from all solvents by both methods. The β-form is obtained only in carefully controlled conditions from water and ethyl acetate, well below the transition temperature. Often the α-form appears concomitantly.

It is shown in this work that sonication significantly reduces the induction time for nucleation. The β-form crystallizes more reproducibly and at higher cooling rates when controlled sonication is used. In addition sonication is found to selectively favor the appearance of one of the polymorphs. Producing the pure β-form was possible even above the transition temperature where other crystallization techniques were only capable of producing the stable α-form. The α-form structure is based on centro symmetric dimers formed by association of carboxylic acid groups. It is suggested that the preference for nucleation of the α-polymorph is related to the formation of dimers in the supersaturated solution. Only at the condition where the formation of dimers is reduced sufficiently, (i.e. in the polar solvents or when sonication is applied) the nucleation of the β-form is favored.

Place, publisher, year, edition, pages
Stockholm: KTH, 2005. viii, 63 p.
Trita-KET, ISSN 1104-3466 ; 215
Chemical engineering, solubility, prediction of solubility, UNIFAC, activity coefficients, activity of the solid phase, polymorphism, controlled crystallization, sonication., Kemiteknik
National Category
Chemical Engineering
urn:nbn:se:kth:diva-267 (URN)91-7178-077-7 (ISBN)
Public defence
2005-06-17, Sal E3, Lindstedtsvägen 3, Stockholm, 12:00
QC 20101014Available from: 2005-06-07 Created: 2005-06-07 Last updated: 2010-10-14Bibliographically approved

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Gracin, SandraSvärd, MichaelFischer, Andreas
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