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The cortex as a central pattern generator
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
2005 (English)In: Nature Reviews Neuroscience, ISSN 1471-0048, E-ISSN 1471-003X, Vol. 6, no 6, 477-483 p.Article, review/survey (Refereed) Published
Abstract [en]

Vertebrate spinal cord and brainstem central pattern generator (CPG) circuits share profound similarities with neocortical circuits. CPGs can produce meaningful functional output in the absence of sensory inputs. Neocortical circuits could be considered analogous to CPGs as they have rich spontaneous dynamics that, similar to CPGs, are powerfully modulated or engaged by sensory inputs, but can also generate output in their absence. We find compelling evidence for this argument at the anatomical, biophysical, developmental, dynamic and pathological levels of analysis. Although it is possible that cortical circuits are particularly plastic types of CPG ('learning CPGs'), we argue that present knowledge about CPGs is likely to foretell the basic principles of the organization and dynamic function of cortical circuits.

Place, publisher, year, edition, pages
2005. Vol. 6, no 6, 477-483 p.
Keyword [en]
pre-botzinger complex, cat visual-cortex, respiratory rhythm generation, spontaneous firing patterns, mammalian spinal-cord, in-vitro, neural-networks, pacemaker neurons, cortical activity, neocortex
URN: urn:nbn:se:kth:diva-14787DOI: 10.1038/nrn1686ISI: 000229502800015ScopusID: 2-s2.0-20044395619OAI: diva2:332828
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2010-09-23Bibliographically approved

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