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A synapse which can switch from inhibitory to excitatory and back
KTH, School of Computer Science and Communication (CSC), Numerical Analysis and Computer Science, NADA.ORCID iD: 0000-0003-0281-9450
2005 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 65, 39-45 p.Article in journal (Refereed) Published
Abstract [en]

Co-release of transmitters has recently been observed at synapse terminals and can even be a combination such as glutamate and GABA. A second recent experimental finding is a short-term synaptic plasticity, which depends on postsynaptic depolarization releasing a dendritic transmitter, which affects presynaptic release probability. In this work we are investigating the functional consequences for a synapse if it had both co-release and conditioning depression. If initially the GABA component is larger than the glutamate component, the synapse has an inhibitory net effect. However, if the postsynaptic cell is conditioned, the GABA component will be suppressed yielding an excitatory synapse.

Place, publisher, year, edition, pages
2005. Vol. 65, 39-45 p.
Keyword [en]
co-release, short-term synaptic plasticity, conditioning depression, pyramidal neurons, visual-cortex, rat neocortex, layer 2/3, glutamate, gaba, hippocampus, plasticity, corelease, release
National Category
Bioinformatics (Computational Biology) Neurosciences
URN: urn:nbn:se:kth:diva-14810DOI: 10.1016/j.neucom.2004.10.085ISI: 000229663600006ScopusID: 2-s2.0-18244407507OAI: diva2:332851
QC 20100525 QC 20111011 QC 20111214Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2011-12-14Bibliographically approved

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Fransén, Erik
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Numerical Analysis and Computer Science, NADA
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