Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The role of background synaptic noise in striatal fast spiking interneurons
KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.ORCID iD: 0000-0002-0550-0739
2005 (English)In: Neurocomputing, ISSN 0925-2312, E-ISSN 1872-8286, Vol. 65, 727-732 p.Article in journal (Refereed) Published
Abstract [en]

Striatal fast spiking (FS) interneurons provide inhibition to each other as well as to medium spiny projection (SP) neurons. They exhibit up-states synchronously with SP neurons, and receive GABAergic and AMPA synaptic input during both up- and down-states. The synaptic input during down-states can be considered noise and might affect detection of up-states. We investigate what role this background noise might play for up-state firing in a 127 compartment FS model neuron. The model has Na, KDr and KA conductances, and is activated through AMPA and GABA synapses. The model's response to current injection and synaptic inputs resembled experimental data. We show that intermediate levels of noise neither facilitates nor degrades the ability of the FS neuron model to detect up-states.

Place, publisher, year, edition, pages
2005. Vol. 65, 727-732 p.
Keyword [en]
striatum, fast spiking interneurons, Stochastic resonance, transient A current, up-states, membrane-potential fluctuations, spiny neurons, neostriatal neurons, rat neostriatum, in-vivo, states
National Category
Medical and Health Sciences Engineering and Technology
Identifiers
URN: urn:nbn:se:kth:diva-14813DOI: 10.1016/j.neucom.2004.10.068ISI: 000229663600094Scopus ID: 2-s2.0-18144367771OAI: oai:DiVA.org:kth-14813DiVA: diva2:332854
Note
QC 20100525 QC 20111011Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Authority records BETA

Hellgren Kotaleski, Jeanette

Search in DiVA

By author/editor
Hellgren Kotaleski, Jeanette
By organisation
Computational Biology, CB
In the same journal
Neurocomputing
Medical and Health SciencesEngineering and Technology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 34 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf