A general method for the preparation of chiral TREN derivatives
2005 (English)In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, no 13, 2835-2840 p.Article in journal (Refereed) Published
A general procedure for the preparation of C-3-symmetric TREN derivatives with backbone chirality has been developed. Stereo- and regioselective ring opening by ammonia of (S)-N-tosyl-2-isopropylaziridine, obtained starting from either the corresponding amino alcohol or amino acid, followed by deprotection of the amino groups afforded the parent chiral TREN compound in high overall yield. In addition to TREN compounds with primary amino groups, the synthetic method employed provides easy access to a variety of N,N',N-substituted derivatives. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).
Place, publisher, year, edition, pages
2005. no 13, 2835-2840 p.
amines, chirality, C-3 symmetry, tripodal ligands, TREN, direct alpha-arylation, aryl chlorides, triamidoamine ligands, catalytic-reduction, mediated addition, c-3 symmetry, aziridines, complexes, molybdenum, contain
IdentifiersURN: urn:nbn:se:kth:diva-14881DOI: 10.1002/ejoc.200500094ISI: 000230247400024ScopusID: 2-s2.0-22144498455OAI: oai:DiVA.org:kth-14881DiVA: diva2:332922
QC 201005252010-08-052010-08-05Bibliographically approved