Biophysically detailed modelling of microcircuits and beyond
2005 (English)In: TINS - Trends in Neurosciences, ISSN 0166-2236, E-ISSN 1878-108X, Vol. 28, no 10, 562-569 p.Article, review/survey (Refereed) Published
Realistic bottom-up modelling has been seminal to understanding which properties of microcircuits control their dynamic behaviour, such as the locomotor rhythms generated by central pattern generators. In this article of the TINS Microcircuits Special Feature, we review recent modelling work on the leech-heartbeat and lamprey-swimming pattern generators as examples. Top-down mathematical modelling also has an important role in analyzing microcircuit properties but it has not always been easy to reconcile results from the two modelling approaches. Most realistic microcircuit models are relatively simple and need to be made more detailed to represent complex processes more accurately. We review methods to add neuromechanical feedback, biochemical pathways or full dendritic morphologies to microcircuit models. Finally, we consider the advantages and challenges of full-scale simulation of networks of microcircuits.
Place, publisher, year, edition, pages
2005. Vol. 28, no 10, 562-569 p.
central pattern generator, long-term depression, heartbeat neuronal network, intersegmental phase-lag, cerebellar purkinje-cell, neural mechanisms, signal-transduction, inhibitory neurons, synaptic currents, timing network
Bioinformatics (Computational Biology)
IdentifiersURN: urn:nbn:se:kth:diva-15099DOI: 10.1016/j.tins.2005.08.002ISI: 000232478600009PubMedID: 16118023ScopusID: 2-s2.0-24944584124OAI: oai:DiVA.org:kth-15099DiVA: diva2:333140
QC 201005252010-08-052010-08-052012-01-08Bibliographically approved