Change search
ReferencesLink to record
Permanent link

Direct link
Increased levels of interstitial potassium but normal levels of muscle IL-6 and LDH in patients with trapezius myalgia
Show others and affiliations
2005 (English)In: Pain, ISSN 0304-3959, E-ISSN 1872-6623, Vol. 119, no 03-jan, 201-209 p.Article in journal (Refereed) Published
Abstract [en]

The mechanisms behind the development of work-related trapezius pain are suggested to involve both peripheral and central components, but the specific contribution of alterations in muscle nociceptive and other substances is not clear. Female patients with chronic trapezius myalgia (N = 19; TM) and female controls (N = 20; CON) were studied at rest, during 20 min repetitive low-force exercise and recovery, and had their interstitial concentrations of potassium (K+), lactate dehydrogenase (LDH), interleukin-6 (IL-6) and collagen turnover determined in the trapezius muscle by the microdialysis technique. K+ levels were at all time points higher in TM than in CON (P < 0.0001). Baseline levels of LDH and IL-6 were similar in both groups. In response to exercise pain intensity, rated perceived exertion, and the concentrations of K+, LDH and IL-6 increased significantly in both groups. [K+] immediately decreased to baseline levels in CON but remained elevated during the first 20 min of recovery in TM (P < 0.01) whereafter it returned to baseline level. In all subjects taken together mean [K+] correlated negatively with pressure pain threshold of trapezius (P < 0.001), positively with mean pain intensity VAS (P < 0.001) and mean perceived exertion (P < 0.001). Rises in muscle LDH and IL-6 as well as the anabolic ratio for collagen type I was not significantly different between groups. In conclusion, patients with chronic pain in the trapezius muscle had increased levels of interstitial potassium. This finding could be causally related to myalgia or secondary to pain due to deconditioned muscle or altered muscle activity pattern.

Place, publisher, year, edition, pages
2005. Vol. 119, no 03-jan, 201-209 p.
Keyword [en]
collagen, lactate dehydrogenase, pain, potassium, trapezius, interleukin-6, human skeletal-muscle, ragged-red fibers, female cleaners, healthy controls, cell-damage, exercise, microdialysis, humans, interleukin-6, k+
URN: urn:nbn:se:kth:diva-15300DOI: 10.1016/j.pain.2005.09.026ISI: 000234355900023OAI: diva2:333341
QC 20100525Available from: 2010-08-05 Created: 2010-08-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Peolsson, Michael
In the same journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 25 hits
ReferencesLink to record
Permanent link

Direct link