Change search
ReferencesLink to record
Permanent link

Direct link
Pore size distributions of biodegradable polymer microparticles in aqueous environments measured by NMR cryoporometry
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Physical Chemistry.ORCID iD: 0000-0002-0231-3970
Show others and affiliations
2006 (English)In: Internation Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 309, no 02-jan, 157-162 p.Article in journal (Refereed) Published
Abstract [en]

NMR cryoporometry is a unique method permitting the investigation of pores in the microporous and mesoporous regimes for samples in aqueous environments. Here, we apply the technique to porous biodegradable polymer microparticles designed as devices for drug delivery in depot formulations. The results indicate that structural features too small to be captured in surface and fracture images obtained by SEM are able to be accessed using the technique, and that the evolution of pore structure can be studied for several days as the particles swell and degrade in the aqueous environment.

Place, publisher, year, edition, pages
2006. Vol. 309, no 02-jan, 157-162 p.
Keyword [en]
microparticles, drug release, pore size distribution, swelling, degradation, NMR cryoporometry, SEM, differential scanning calorimetry, nuclear-magnetic-resonance, porous solids, drug-release, microspheres, protein, water, poly(d,l-lactide-co-glycolide), thermoporosimetry, hydrogel
URN: urn:nbn:se:kth:diva-15452DOI: 10.1016/j.ijpharm.2005.11.027ISI: 000235571400021OAI: diva2:333493
QC 20100525Available from: 2010-08-05 Created: 2010-08-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Furo, Istvan
By organisation
Physical Chemistry
In the same journal
Internation Journal of Pharmaceutics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 87 hits
ReferencesLink to record
Permanent link

Direct link