Pore size distributions of biodegradable polymer microparticles in aqueous environments measured by NMR cryoporometry
2006 (English)In: Internation Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 309, no 02-jan, 157-162 p.Article in journal (Refereed) Published
NMR cryoporometry is a unique method permitting the investigation of pores in the microporous and mesoporous regimes for samples in aqueous environments. Here, we apply the technique to porous biodegradable polymer microparticles designed as devices for drug delivery in depot formulations. The results indicate that structural features too small to be captured in surface and fracture images obtained by SEM are able to be accessed using the technique, and that the evolution of pore structure can be studied for several days as the particles swell and degrade in the aqueous environment.
Place, publisher, year, edition, pages
2006. Vol. 309, no 02-jan, 157-162 p.
microparticles, drug release, pore size distribution, swelling, degradation, NMR cryoporometry, SEM, differential scanning calorimetry, nuclear-magnetic-resonance, porous solids, drug-release, microspheres, protein, water, poly(d,l-lactide-co-glycolide), thermoporosimetry, hydrogel
IdentifiersURN: urn:nbn:se:kth:diva-15452DOI: 10.1016/j.ijpharm.2005.11.027ISI: 000235571400021OAI: oai:DiVA.org:kth-15452DiVA: diva2:333493
QC 201005252010-08-052010-08-05Bibliographically approved