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Crystal structure and physical properties of two polymorphs of ropivacaine HCl
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Inorganic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Inorganic Chemistry.
2006 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 95, no 3, 680-688 p.Article in journal (Refereed) Published
Abstract [en]

The crystal structure of two polymorphs of ropivacaine HCl have been determined, as well as their relative stability up to 100 degrees C. A geometric restriction for a solid-state transition between the two polymorphs has been identified. The packing density along the H-bonded chains form the basis for a model explaining the kinetic crystallization of the metastable form. The difference in stability and physicochemical properties between the two polymorphs can be attributed to the difference in crystal structure.

Place, publisher, year, edition, pages
2006. Vol. 95, no 3, 680-688 p.
Keyword [en]
crystal structure, polymorphism, physical stability, solution calorimetry, solubility, solid state, thermodynamics
Identifiers
URN: urn:nbn:se:kth:diva-15547DOI: 10.1002/jps.20518ISI: 000236266600016Scopus ID: 2-s2.0-33645328041OAI: oai:DiVA.org:kth-15547DiVA: diva2:333588
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved

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Fischer, AndreasKloo, Lars A.
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