Parallel synthesis of an indole-based library via an iterative Mannich reaction sequence
2006 (English)In: Tetrahedron, ISSN 0040-4020, E-ISSN 1464-5416, Vol. 62, no 14, 3439-3445 p.Article in journal (Refereed) Published
A library of 1,3-disubstituted indoles has been prepared via an iterative Mannich reaction sequence. The first Mannich reaction with secondary amines and formaldehyde preferentially yields 3-aminomethyl indoles, while the second Mannich reaction introduces an additional aminomethyl group at the N1-position of the indole ring. A library of 25 substituted indoles has thus been prepared in moderate to good yields with purity.
Place, publisher, year, edition, pages
2006. Vol. 62, no 14, 3439-3445 p.
library synthesis, Mannich reaction, affinity ligands, receptor par-1 antagonists, solid-phase synthesis, multiple-quantum nmr, peptide mimetics
IdentifiersURN: urn:nbn:se:kth:diva-15575DOI: 10.1016/j.tet.2006.01.047ISI: 000236486100027ScopusID: 2-s2.0-33644901060OAI: oai:DiVA.org:kth-15575DiVA: diva2:333616
QC 201005252010-08-052010-08-05Bibliographically approved