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Parallel synthesis of an indole-based library via an iterative Mannich reaction sequence
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
2006 (English)In: Tetrahedron, ISSN 0040-4020, E-ISSN 1464-5416, Vol. 62, no 14, 3439-3445 p.Article in journal (Refereed) Published
Abstract [en]

A library of 1,3-disubstituted indoles has been prepared via an iterative Mannich reaction sequence. The first Mannich reaction with secondary amines and formaldehyde preferentially yields 3-aminomethyl indoles, while the second Mannich reaction introduces an additional aminomethyl group at the N1-position of the indole ring. A library of 25 substituted indoles has thus been prepared in moderate to good yields with purity.

Place, publisher, year, edition, pages
2006. Vol. 62, no 14, 3439-3445 p.
Keyword [en]
library synthesis, Mannich reaction, affinity ligands, receptor par-1 antagonists, solid-phase synthesis, multiple-quantum nmr, peptide mimetics
URN: urn:nbn:se:kth:diva-15575DOI: 10.1016/j.tet.2006.01.047ISI: 000236486100027ScopusID: 2-s2.0-33644901060OAI: diva2:333616
QC 20100525Available from: 2010-08-05 Created: 2010-08-05Bibliographically approved

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Somfai, Peter
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Organic Chemistry
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