Uncertainty and the ethics of clinical trials
2006 (English)In: Theoretical Medicine and Bioethics, ISSN 1386-7415, E-ISSN 1573-1200, Vol. 27, no 2, 149-167 p.Article in journal (Refereed) Published
A probabilistic explication is offered of equipoise and uncertainty in clinical trials. In order to be useful in the justification of clinical trials, equipoise has to be interpreted in terms of overlapping probability distributions of possible treatment outcomes, rather than point estimates representing expectation values. Uncertainty about treatment outcomes is shown to be a necessary but insufficient condition for the ethical defensibility of clinical trials. Additional requirements are proposed for the nature of that uncertainty. The indecisiveness of our criteria for cautious decision-making under uncertainty creates the leeway that makes clinical trials defensible.
Place, publisher, year, edition, pages
2006. Vol. 27, no 2, 149-167 p.
cautiousness, clinical decision-making, clinical trials, equipoise, uncertainty, placebo-controlled trials, community-equipoise, principle, benefits, neednt, risks, time
IdentifiersURN: urn:nbn:se:kth:diva-15673DOI: 10.1007/s11017-006-0001-yISI: 000237562400003ScopusID: 2-s2.0-33646582379OAI: oai:DiVA.org:kth-15673DiVA: diva2:333715
QC 201005252010-08-052010-08-05Bibliographically approved