The use of polymer design in resorbable colloids
2006 (English)In: Annual review of materials research (Print), ISSN 1531-7331, E-ISSN 1545-4118, Vol. 36, 369-395 p.Article, review/survey (Refereed) Published
During the past decade, researchers in the field of polymer chemistry have developed a wide range of very powerful procedures for constructing ever-more-sophisticated polymers. These methods subsequently have been used in suitable systems to solve specific medical problems. This is complicated, and many key factors such as mechanical properties, biocompatibility, biodegradation, stability, and degradation profile must be considered. Colloid particle systems can be used to solve many biomedical- and pharmaceutical-related problems, and it is expected that nanotechnology can be used to develop these materials, devices, and systems even further. For example, an injectible scaffold system with a defined release and degradation profile has huge potential for the repair and regeneration of damaged tissues. This short, nonexhaustive review presents examples of polymer architecture in resorbable particles that have been compared and tested in biomedical applications. We also discuss the design of polymers for core-shell structures.
Place, publisher, year, edition, pages
2006. Vol. 36, 369-395 p.
resorbable polymers, architecture, properties, biomedical applications, ring-opening polymerization, drug-delivery systems, in-vitro degradation, double-walled microspheres, biodegradable microspheres, controlled-release, surface modification, block-copolymers, poly(ethylene glycol), triblock copolymers
IdentifiersURN: urn:nbn:se:kth:diva-15923DOI: 10.1146/annurev.matsci.36.032905.091005ISI: 000239807500013ScopusID: 2-s2.0-33749184496OAI: oai:DiVA.org:kth-15923DiVA: diva2:333965
QC 201005252010-08-052010-08-05Bibliographically approved