Change search
ReferencesLink to record
Permanent link

Direct link
Achieving directed immunostimulating complex incorporation
Show others and affiliations
2006 (English)In: Expert Review of Vaccines, ISSN 1476-0584, Vol. 5, no 3, 395-403 p.Article, review/survey (Refereed) Published
Abstract [en]

In recent years, several studies have been reported with the common aim of generating general expression systems for straightforward production and subsequent coupling of expressed antigens to an adjuvant system. Here, we describe a series of such efforts with a common theme of using gene fusion technology for association of recombinant antigens to immunostimulating complexes (iscoms). In the early stages of vaccine development, uniform antigen preparations are crucial to allow the comparison of immune responses to different antigens, or even subdomains thereof, and we believe that the described systems constitute an important development in this context.

Place, publisher, year, edition, pages
2006. Vol. 5, no 3, 395-403 p.
Keyword [en]
adjuvant, affinity purification, fusion protein, iscom, subunit vaccine, falciparum antigen pf155/resa, solubilizing fusion partner, direct iscom incorporation, aqueous 2-phase systems, escherichia-coli, recombinant immunogens, bacterial expression, toxoplasma-gondii, protein-a, peptide
URN: urn:nbn:se:kth:diva-16023DOI: 10.1586/14760584.5.3.395ISI: 000240921700017ScopusID: 2-s2.0-33746786432OAI: diva2:334065
QC 20100525Available from: 2010-08-05 Created: 2010-08-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Ståhl, Stefan
By organisation
Molecular Biotechnology
In the same journal
Expert Review of Vaccines

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link