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Achieving directed immunostimulating complex incorporation
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2006 (English)In: Expert Review of Vaccines, ISSN 1476-0584, E-ISSN 1744-8395, Vol. 5, no 3, 395-403 p.Article, review/survey (Refereed) Published
Abstract [en]

In recent years, several studies have been reported with the common aim of generating general expression systems for straightforward production and subsequent coupling of expressed antigens to an adjuvant system. Here, we describe a series of such efforts with a common theme of using gene fusion technology for association of recombinant antigens to immunostimulating complexes (iscoms). In the early stages of vaccine development, uniform antigen preparations are crucial to allow the comparison of immune responses to different antigens, or even subdomains thereof, and we believe that the described systems constitute an important development in this context.

Place, publisher, year, edition, pages
2006. Vol. 5, no 3, 395-403 p.
Keyword [en]
adjuvant, affinity purification, fusion protein, iscom, subunit vaccine, falciparum antigen pf155/resa, solubilizing fusion partner, direct iscom incorporation, aqueous 2-phase systems, escherichia-coli, recombinant immunogens, bacterial expression, toxoplasma-gondii, protein-a, peptide
Identifiers
URN: urn:nbn:se:kth:diva-16023DOI: 10.1586/14760584.5.3.395ISI: 000240921700017Scopus ID: 2-s2.0-33746786432OAI: oai:DiVA.org:kth-16023DiVA: diva2:334065
Note
QC 20100525Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2017-12-12Bibliographically approved

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Ståhl, Stefan

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