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Prone mammoPET acquisition improves the ability to fuse MRI and PET breast scans
New York University, Department of Radiology.
New York University, Department of Radiology. (Nuclear Medicine)
KTH, School of Information and Communication Technology (ICT), Communication Systems, CoS. (Computer Communications)ORCID iD: 0000-0002-6066-746X
New York University, Department of Radiology.
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2007 (English)In: Clinical Nuclear Medicine, ISSN 0363-9762, E-ISSN 1536-0229, Vol. 32, no 3, 194-198 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: This study compared prone acquisition of PET scans with traditional supine acquisition to improve fusion of PET scans with MRI scans and improve evaluation of enhancing breast lesions detected on MRI. Materials and Methods: MRI breast scans are acquired in the prone position using a breast coil to allow the breasts to hang pendant. An apparatus was fabricated to allow prone acquisition of PET scans. Fused scans from 2 patients acquired both prone and supine were contrasted with those from 3 patients acquired supine only. All 5 MRI scans were acquired on standard scanners. The PET scans were acquired with a PET/CT unit using a low-dose CT scan for attenuation correction. The PET and MRI volumes were matched twice (using a semiautomated registration method) by different operators. The additional value of fusion was judged using reports from the original (nonfused) MRI and PET, joint rereading of the volumes side by side, and examination of fused images. Results: Of 12 enhancing lesions on breast MRI, 7 demonstrated uptake on PET/CT. In the 3 supine-only cases, the fused images were not interpretable because of the marked distortion of the breasts. In the 2 prone cases, the fused images increased our confidence in characterizing a lesion as benign or malignant. Interpretations were confirmed by clinical follow up in 2 or histologic results in 3 patients. Conclusions: PET MRI fusion is feasible and may assist in localizing lesions detected on either study. A more extensive study is under-way to confirm the value of this fusion technique.

Place, publisher, year, edition, pages
Philadephia, Pennsylvania, USA: Lippincott Williams & Wilkins , 2007. Vol. 32, no 3, 194-198 p.
Keyword [en]
PET/MRI fusion, breast cancer, improving MRI specificity, prone PET breast acquisition, fdg pet, cancer, women, mammography, experience, risk
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
URN: urn:nbn:se:kth:diva-16419DOI: 10.1097/01.rlu.0000255055.10177.80ISI: 000244553900004PubMedID: 17314593ScopusID: 2-s2.0-33847214505OAI: diva2:334461
QC 20100525 QC 20120119Available from: 2010-08-05 Created: 2010-08-05 Last updated: 2013-09-09Bibliographically approved

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Maguire Jr., Gerald Q.
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Communication Systems, CoS
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